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. 2022 Sep-Oct;140(5):682-690.
doi: 10.1590/1516-3180.2021.0549.R1.03012022.

Association between bone mineral density and content and physical growth parameters among children and adolescents diagnosed with HIV: a cross-sectional study

Suellem Zanlorenci  1 , Priscila Custódio Martins  2 , Carlos Alencar Souza Alves Junior  2 , João Antônio Chula de Castro  2 , Luiz Rodrigo Augustemak de Lima  3 , Edio Luiz Petroski  4 , Diego Augusto Santos Silva  5
Affiliations

Association between bone mineral density and content and physical growth parameters among children and adolescents diagnosed with HIV: a cross-sectional study

Suellem Zanlorenci et al. Sao Paulo Med J. 2022 Sep-Oct.

Abstract

Background: During childhood and adolescence, there are significant increases in bone mineral content (BMC) and bone mineral density (BMD).

Objective: To investigate physical growth parameters associated with BMD and BMC among children and adolescents diagnosed with human immunodeficiency virus (HIV).

Design and setting: Cross-sectional study conducted in Florianópolis, Brazil, among 63 children and adolescents (aged 8-15 years) diagnosed with HIV.

Method: BMD, BMC and fat percentage z score were evaluated using dual X-ray absorptiometry. Age/height z score and body mass index (BMI)/age z score were obtained in accordance with international recommendations, and bone age was obtained through hand-wrist radiography. Sex, family income, information on HIV infection (T CD4+ lymphocyte count, viral load and type of antiretroviral therapy, moderate-vigorous physical activity and sedentary behavior) were used as adjustment variables in the analyses. Simple and multiple linear regression analyses were performed, with a significance level of P ≤ 0.05.

Results: Subtotal BMD (without the head region) was directly associated with bone age, BMI/age z score and fat percentage z score, even after adjusting for covariates. Subtotal BMC/height was directly associated with bone age, height/age z score, BMI/age z score and fat percentage z score, even after adjusting for covariates.

Conclusion: Subtotal BMD and subtotal BMC/height were directly associated with physical growth indicators among children and adolescents diagnosed with HIV.

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Conflict of interest statement

Conflict of interest: None

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