Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Oct;69(10):e29900.
doi: 10.1002/pbc.29900. Epub 2022 Aug 3.

Extrarenal Wilms tumor with hypertension and dilated cardiomyopathy in an infant: A report of an unusual case

Yan-Ning Qu  1 , Yu-Rui Wu  2 , Dong Qu  1 , Hai-Yan Ge  1
Affiliations
Case Reports

Extrarenal Wilms tumor with hypertension and dilated cardiomyopathy in an infant: A report of an unusual case

Yan-Ning Qu et al. Pediatr Blood Cancer. 2022 Oct.

Abstract

While Wilms tumors are the most frequently detected kidney cancer type in children, extrarenal Wilms tumors (ERWTs) remain rare. This report is the first to describe hypertension and dilated cardiomyopathy in a patient with an ERWT. A 6-month-old male infant presented with an abdominal mass and paroxysmal hypertension; echocardiography revealed dilated cardiomyopathy with an ejection fraction of 34%, as well as substantially increased plasma renin activity. Pathology yielded a definitive diagnosis of ERWT. Cardiac function and blood pressure gradually returned to normal after tumorectomy. The early diagnosis of such a tumor together with efficient oncologic treatment are vital to optimal patient outcomes.

Keywords: case report; congestive heart failure (CHF); dilated cardiomyopathy; extrarenal Wilms tumor (ERWT); hypertension.

PubMed Disclaimer

References

REFERENCES

    1. Szychot E, Apps J, Pritchard-Jones K. Wilms' tumor: biology, diagnosis and treatment. Transl Pediatr. 2014;3:12-24.
    1. Liang H, He Y, Fu L, et al. Extrarenal Wilms tumor in children: a retrospective observational case series. J Pediatr Urol. 2020;16:664.e1-664.e7.
    1. Friedman AD. Wilms tumor. Pediatr Rev. 2013;34:328-330. Discussion 330.
    1. Dome JS, Graf N, Geller JI, et al. Advances in Wilms tumor treatment and biology: progress through international collaboration. J Clin Oncol. 2015;33:2999-3007.
    1. Madre C, Orbach D, Baudouin V, et al. Hypertension in childhood cancer: a frequent complication of certain tumor sites. J Pediatr Hematol Oncol. 2006;28:659-664.

Publication types

LinkOut - more resources