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. 2022 Dec;54(1):2204-2210.
doi: 10.1080/07853890.2022.2107700.

Risk factors for ophthalmologic involvement and ocular findings in patients diagnosed with fungemia in a high-complexity hospital in the city of Medellín, Colombia

Marcos Restrepo Arango  1 , Juan Camilo Cadavid Usuga  1 , Luis Fernando Velazquez Ossa  2 , Jorge Hernando Donado Gómez  3 , Laura Nataly Higuita Duque  2 , Juan Pedro Neira Gomez  1
Affiliations

Risk factors for ophthalmologic involvement and ocular findings in patients diagnosed with fungemia in a high-complexity hospital in the city of Medellín, Colombia

Marcos Restrepo Arango et al. Ann Med. 2022 Dec.

Abstract

Purpose: To describe the demographic clinical characteristics and to identify the risk factors of patients diagnosed with fungemia and secondary intraocular involvement.

Methods: Retrospective cohort of 97 patients diagnosed with fungemia and with or without involvement of the posterior segment. Demographic, clinical and ophthalmological variables were identified to establish the risk of retinal seeding.

Results: An incidence of ocular involvement of 22.68% was obtained and no clear risk factor was found for subsequent showings in patients with fungemia. A risk trend was only found in patients with diabetes with an OR: 2.85; CI 95%: (0.80-10.12) and history of HIV with an OR: 2.29 CI95%: (0.85-6.12).

Conclusions: In this first cohort carried out in Colombia according to our search, findings were obtained that agree with those of other authors worldwide, where there is no evidence of a decrease in incidence compared with older studies and the absence of risk factors for the compromise of the posterior pole in patients with fungemia.KEY MESSAGESSystematic fundus evaluation by an ophthalmologist in patients with candidaemia is a recommended practice based on low-quality evidence.The identification of real risk factors for retinal compromise in fungemia would allow us to be more selective with the population to be evaluated.Fungemia generally occurs in critically ill patients, where access and availability of ophthalmology evaluation are a resource that is not always available.

Keywords: Fundus Oculi; Fungemia; candida; retina.

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Conflict of interest statement

None of the author have any proprietary interests or conflicts of interest related to this submission

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References

    1. Guna Serrano MR, Larrosa Escartín N, Marín Arriaza M, et al. . Diagnóstico microbiológico de la bacteriemia y la fungemia: hemocultivos y métodos moleculares. Enferm Infecc Microbiol Clin. 2019;37(5):335–340. - PubMed
    1. Figueras C, Heredia C d, García JJ, et al. . Recomendaciones de la sociedad española de infectología pediátrica sobre diagnóstico y tratamiento de la candidiasis invasiva. Anal Pediatr. 2011;74(5):337.e1-337.e17–337.e17. - PubMed
    1. Cervera C. Candidemia y candidiasis invasora en el adulto. Formas clínicas y tratamiento. Enfermed Infec Microbiol Clín. 2012;30(8):483–491. - PubMed
    1. Oude Lashof AML, Rothova A, Sobel JD, et al. . Ocular manifestations of candidemia. Clin Infect Dis. 2011;53(3):262–268. - PubMed
    1. Breazzano MP, Day HR, Bloch KC, et al. . Utility of ophthalmologic screening for patients with Candida bloodstream infections: a systematic review. JAMA Ophthalmol. 2019;137(6):698–710. - PubMed

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