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Review
. 2022 Nov;395(11):1331-1341.
doi: 10.1007/s00210-022-02277-5. Epub 2022 Aug 3.

Targeting ferroptosis in ischemia/reperfusion renal injury

Komal Thapa  1   2 , Thakur Gurjeet Singh  3 , Amarjot Kaur  1
Affiliations
Review

Targeting ferroptosis in ischemia/reperfusion renal injury

Komal Thapa et al. Naunyn Schmiedebergs Arch Pharmacol. 2022 Nov.

Abstract

Renal I/R injury is a severe medical condition contributing to acute kidney injury (AKI), leading to rapid kidney dysfunction and high mortality rates. It is generally observed during renal transplantation, shock, trauma, and urologic and cardiovascular surgery, for which there is no effective treatment. Cell death and damage are commonly linked to I/R. Cell death triggered by iron-dependent lipid peroxidation, such as ferroptosis, has been demonstrated to have a significant detrimental effect in renal IRI models, making it a new type of cell death currently being researched. Ferroptosis is a nonapoptotic type of cell death that occurs when free iron enters the cell and is a critical component of many biological processes. In ferroptosis-induced renal I/R injury, iron chelators such as Deferasirox, Deferiprone, and lipophilic antioxidants are currently suppressed lipid peroxidation Liproxstatin-1 (Lip-1), Ferrostatin-1 along with antioxidants like vitamin and quercetin. Ferroptosis has been considered a potential target for pharmaceutical intervention to alleviate renal IRI-associated cell damage. Thus, this review emphasized the role of ferroptosis and its inhibition in renal IRI. Also, Pharmacological modulation of ferroptosis mechanism in renal I/R injury has been conferred. Graphical abstract.

Keywords: Ferroptosis inhibitors; Heme oxygenase-1; Mechanism of ferroptosis; Pannexin signaling; Renal I/R injury; Therapeutic targets; miRNAs.

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