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. 2022;15(5):648-654.
doi: 10.1159/000525555. Epub 2022 Aug 3.

Risk Factors Influencing Seroconversion after Inactive SARS-CoV-2 Vaccination in People Living with Obesity

Zehra Kara  1   2 , Rüveyda Akçin  3 , Ahmet Numan Demir  1   2 , Harika Öykü Dinç  3   4 , Bekir Kocazeybek  3 , Volkan Demirhan Yumuk  1   2
Affiliations

Risk Factors Influencing Seroconversion after Inactive SARS-CoV-2 Vaccination in People Living with Obesity

Zehra Kara et al. Obes Facts. 2022.

Abstract

Introduction: The aim of this study was to investigate the antibody titers against SARS-CoV-2 spike antigens and the risk factors affecting antibody levels in people living with obesity (PwO) after inactive SARS-CoV-2 vaccine (CoronaVac) administration.

Methods: 169 consecutive patients with obesity who visited the Center for Obesity Management at Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty Hospitals, between May and August 2021, were invited to the study. The nonobese control group was recruited from 191 subjects who visited the Cerrahpaşa Hospitals Vaccination Unit. The study group and the nonobese control group have already received two doses of inactive SARS-CoV-2 vaccine. The SARS-CoV-2 IgG nucleocapsid antibody test was administered to patients and control subjects to discover those who had prior SARS-CoV-2 infection. Forty-one patients who had prior infection and received two doses of vaccine were also included in the study as a subgroup. Blood samples were taken on the 3rd to 4th week after the second vaccination. SARS-CoV-2 IgG antibody titers were determined by quantitative serological methods.

Results: Antibody titers against SARS-CoV-2 spike antigen of individuals with BMI ≥30.0 kg/m2 were significantly lower than those with BMI <30 kg/m2 (p = 0.001) in the study group. Moreover, the antibody titers in people with BMI ≥30.0 kg/m2 were significantly lower than in those having a BMI <30.0 kg/m2 in the subgroup (p = 0.03). Age (p = 0.03), BMI (p = 0.006), and hypertension (p = 0.03) were found to be independent risk factors for antibody response in PwO. Women with non-prior SARS-CoV-2 infection showed a significantly higher antibody response then men (p = 0.001).

Conclusion: SARS-CoV-2-Immunoglobulin G antibody levels against inactive (CoronaVac) vaccine were found to be lower in PwO compared to nonobese individuals. Antibody titers may be measured, and booster doses should be delivered accordingly in PwO for optimal protection.

Keywords: Antibody response; Obesity; Vaccination.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

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References

    1. Centers for Disease Control and Prevention . Centers for disease control and prevention 2019 Novel Coronavirus. Wuhan, China: Centers for Disease Control and Prevention; 2020. Available from: www.cdc.gov/coronavirus/2019-ncov/about/index.html (accessed January 27, 2020)
    1. Wee S-L, McNeil GD, Hernández JCWHO. declares global emergency as Wuhan coronavirus spreads. New York Times: 2020.
    1. World Health Organization World Health Organization COVID-19 Vaccines. 2019. Available from: www.who.int/emergencies/diseases/novel-coronavirus-2019/covid-19-vaccines (accessed January 20, 2021)
    1. Republic of Turkey Ministry of Health Turkish Republic Ministry of Health COVID-19 vaccine information platform. 2022. Available from: www.covid19asi.saglik.gov.tr (accessed January 20, 2022)
    1. World Health Organization WHO fact sheet on overweight and obesity. 2021. (accessed November 26, 2021)

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