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. 2022 Aug 2;34(8):1079-1081.
doi: 10.1016/j.cmet.2022.07.001.

Using the urea cycle to shift astrocytes from harmful to helpful in Alzheimer's disease

Ariel K Frame  1 , Robert C Cumming  2
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Using the urea cycle to shift astrocytes from harmful to helpful in Alzheimer's disease

Ariel K Frame et al. Cell Metab. .
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Abstract

Astrocytes are brain cells that react to Alzheimer's disease pathology in ways that can have either beneficial or detrimental effects. In this issue of Cell Metabolism, Ju et al. outline a novel strategy for coercing astrocytes to a neuroprotective state by maintaining liver-like detoxification in the brain without producing damaging byproducts.

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Declaration of interests The authors declare no competing interests.

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