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. 2022 Aug 2;34(8):1081-1082.
doi: 10.1016/j.cmet.2022.07.008.

T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?

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T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?

Michael P Cancro. Cell Metab. .
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Abstract

Obesity is linked to inflammation and downstream metabolic dysregulation. In this issue of Cell Metabolism, Hägglöf et al. show that iNKT cells enable the accumulation of T-bet+ B cells in white adipose tissue, which in turn produce chemokine and antibody mediators that exacerbate the onset and severity of metabolic disease.

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Declaration of interests The author declares no competing interests.

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