T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?
- PMID: 35921814
- DOI: 10.1016/j.cmet.2022.07.008
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?
Abstract
Obesity is linked to inflammation and downstream metabolic dysregulation. In this issue of Cell Metabolism, Hägglöf et al. show that iNKT cells enable the accumulation of T-bet+ B cells in white adipose tissue, which in turn produce chemokine and antibody mediators that exacerbate the onset and severity of metabolic disease.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity.Cell Metab. 2022 Aug 2;34(8):1121-1136.e6. doi: 10.1016/j.cmet.2022.07.002. Epub 2022 Jul 21. Cell Metab. 2022. PMID: 35868310 Free PMC article.
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