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Comment
. 2022 Aug 2;34(8):1083-1085.
doi: 10.1016/j.cmet.2022.07.004.

Gluconeogenesis: Adding a new piece to the puzzle of malaria parasitism

Kely C Matteucci  1 , Theresa R Ramalho  2 , Isabella C Hirako  3 , Ricardo T Gazzinelli  4
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Free article
Comment

Gluconeogenesis: Adding a new piece to the puzzle of malaria parasitism

Kely C Matteucci et al. Cell Metab. .
Free article

Abstract

Disorders of carbohydrate metabolism, including hypoglycemia and lactic acidosis, are common features of malaria. In this issue of Cell Metabolism, Ramos et al. report that regulation of gluconeogenesis and glycemia by the host glucose-6-phosphatase catalytic subunit 1 (G6Pc1) is a key metabolic step that affects both Plasmodium replication and clinical outcome of disease.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • A hypometabolic defense strategy against malaria.
    Ramos S, Ademolue TW, Jentho E, Wu Q, Guerra J, Martins R, Pires G, Weis S, Carlos AR, Mahú I, Seixas E, Duarte D, Rajas F, Cardoso S, Sousa AGG, Lilue J, Paixão T, Mithieux G, Nogueira F, Soares MP. Ramos S, et al. Cell Metab. 2022 Aug 2;34(8):1183-1200.e12. doi: 10.1016/j.cmet.2022.06.011. Epub 2022 Jul 15. Cell Metab. 2022. PMID: 35841892

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