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. 2022 Nov;85(5):573-607.
doi: 10.1016/j.jinf.2022.07.024. Epub 2022 Jul 31.

Robust neutralizing antibody responses after single-dose BNT162b2 vaccination at long intervals from prior SARS-CoV-2 infection and ceiling effect with repeated vaccination

Ji Yun Noh  1 , Hee Jin Cheong  1 , Woo Joo Kim  1 , Ju-Yeon Choi  2 , Hye Won Lee  2 , Sung Soon Kim  2 , Byoungguk Kim  3 , Joon Young Song  4
Affiliations

Robust neutralizing antibody responses after single-dose BNT162b2 vaccination at long intervals from prior SARS-CoV-2 infection and ceiling effect with repeated vaccination

Ji Yun Noh et al. J Infect. 2022 Nov.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
(A) Comparison of paired sera which were collected longitudinally from the study subjects. The geometric mean titer (GMT) of neutralizing antibodies (nAbs) of V1–3 w was higher than that of V2–1 m (n = 12, 7067.7 [95% CI, 5354.1–9329.7] vs. 4916.6 [95% CI, 3470.9–6964.4], P = 0.008) (left). The GMT of nAbs waned from 4954.4 (95% CI, 3986.7–6157.0) at V2–1 m to 2094.9 (95% CI, 1514.3–2898.0) at V2–3 m (n = 25, P<0.001) (middle). The GMT of nAbs of V3–3 w was higher than that of V2–3 m (n = 22, 3320.9 [95% CI, 2585.0–4266.4] vs. 1994.8 [95% CI, 1468.2–2710.2], P<0.001) (right) (B) Kinetics of nAbs against SARS-CoV-2 wild-type, delta, and omicron strains. All available data of titers of nAbs from the study subjects are shown. Black line indicates the GMT of nAbs. V1–3 w, 3 weeks after the first dose; V2–1 m, 1 month after the second dose; V2–3 m, 3 months after the second dose; V3–3 w, 3 weeks after the third dose of BNT162b2; CI, confidence interval.
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