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Comment
. 2022 Oct;23(10):581.
doi: 10.1038/s41576-022-00525-1.

ADAR1 inhibits ZBP1 activation by endogenous Z-RNA

Kirsty Minton  1
Affiliations
Comment

ADAR1 inhibits ZBP1 activation by endogenous Z-RNA

Kirsty Minton. Nat Rev Genet. 2022 Oct.
No abstract available

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Republished in

Comment on

  • ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
    de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J. de Reuver R, et al. Nature. 2022 Jul;607(7920):784-789. doi: 10.1038/s41586-022-04974-w. Epub 2022 Jul 20. Nature. 2022. PMID: 35859175
  • ADAR1 averts fatal type I interferon induction by ZBP1.
    Jiao H, Wachsmuth L, Wolf S, Lohmann J, Nagata M, Kaya GG, Oikonomou N, Kondylis V, Rogg M, Diebold M, Tröder SE, Zevnik B, Prinz M, Schell C, Young GR, Kassiotis G, Pasparakis M. Jiao H, et al. Nature. 2022 Jul;607(7920):776-783. doi: 10.1038/s41586-022-04878-9. Epub 2022 Jul 20. Nature. 2022. PMID: 35859176 Free PMC article.
  • ADAR1 mutation causes ZBP1-dependent immunopathology.
    Hubbard NW, Ames JM, Maurano M, Chu LH, Somfleth KY, Gokhale NS, Werner M, Snyder JM, Lichauco K, Savan R, Stetson DB, Oberst A. Hubbard NW, et al. Nature. 2022 Jul;607(7920):769-775. doi: 10.1038/s41586-022-04896-7. Epub 2022 Jul 20. Nature. 2022. PMID: 35859177 Free PMC article.

References

Original article
    1. Hubbard, N. W. et al. ADAR1 mutation causes ZBP1-dependent immunopathology. Nature https://doi.org/10.1038/s41586-022-04896-7 (2022) - DOI - PubMed
    1. de Reuver, R. et al. ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation. Nature https://doi.org/10.1038/s41586-022-04974-w (2022) - DOI - PubMed
    1. Jiao, H. et al. ADAR1 averts fatal type I interferon induction by ZBP1. Nature https://doi.org/10.1038/s41586-022-04878-9 (2022) - DOI - PubMed - PMC

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