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Comment
. 2022 Aug;608(7921):E1-E10.
doi: 10.1038/s41586-022-04826-7. Epub 2022 Aug 3.

A first update on mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative
Collaborators
Comment

A first update on mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative. Nature. 2022 Aug.
No abstract available

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Conflict of interest statement

A full list of competing interests is supplied as Supplementary Table 11.

Figures

Fig. 1
Fig. 1. Overview of contributing studies in Host Genetics Initiative data freeze 6.
a, Geographical overview of the contributing studies to the COVID-19 Host Genetics Initiative and composition by major continental ancestry groups. Ancestry groups are defined as Middle Eastern (MID), south Asian (SAS), east Asian (EAS), African (AFR), admixed American (AMR) and European (EUR). b, Principal components analysis highlighting the population structure and the sample ancestry of the individuals participating in the COVID-19 Host Genetics Initiative. This figure is reproduced from the original publication by the COVID-19 Host Genetics Initiative with modifications reflecting the updated analysis from data freeze 6.
Fig. 2
Fig. 2. Genome-wide association results for COVID-19.
a, The results of the genome-wide association study of hospitalized COVID-19 (n = 25,027 cases and n = 2,836,272 control individuals) (top), and the results of reported SARS-CoV-2 infection (n = 125,584 cases and n = 2,575,347 control individuals) (bottom). Loci highlighted in yellow (top) represent regions associated with the severity of COVID-19 manifestation. Loci highlighted in green (bottom) are regions associated with SARS-CoV-2-reported infection. Lead variants for the loci identified in this data release are annotated with their respective rs ID. Horizontal lines denote genome-wide significant thresholds. b, The results of gene prioritization using different evidence measures of gene annotation. Genes in regions of linkage disequilibrium (LD), genes with coding variants and eGenes (fine-mapped cis-eQTL variant PIP > 0.1 in GTEx Lung) are annotated if in linkage disequilibrium with a COVID-19 lead variant (r2 > 0.6). V2G denotes the highest gene prioritized by OpenTargetGenetics’ V2G score. The asterisk (*) indicates SARS-CoV-2 reported infection and the plus symbol (+) indicates COVID-19 severity. The transparent loci were reported in the previous freeze (data release 5), and loci in bright blue were identified in the current freeze (data release 6). This figure is reproduced from the original publication by the COVID-19 Host Genetics Initiative with modifications reflecting the updated analysis from data freeze 6.
See this image and copyright information in PMC

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References

    1. The COVID-19 Host Genetics Initiative. The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic. Eu. J. Hum. Genet. 28, 715–718 (2020). - PMC - PubMed
    1. COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature600, 472–477 (2021). - PMC - PubMed
    1. Hobbs, B. D. et al. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat. Genet.49, 426–432 (2017). - PMC - PubMed
    1. Shrine, N. et al. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat. Genet.51, 481–493 (2019). - PMC - PubMed
    1. Hsieh, M.-H. et al. Human surfactant protein D binds spike protein and acts as an entry inhibitor of SARS-CoV-2 pseudotyped viral particles. Front. Immunol.12, 641360 (2021). - PMC - PubMed