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Comment
. 2023 Jan;39(1):173-175.
doi: 10.1007/s12264-022-00932-8. Epub 2022 Aug 3.

Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord

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Comment

Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord

Jing Yang et al. Neurosci Bull. 2023 Jan.
No abstract available

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Figures

Fig. 1
Fig. 1
Specialized CD11c+ microglia in the spinal dorsal horn resolve neuropathic pain via insulin-like growth factor-1 (IGF-1) signaling. Peripheral nerve injury (PNI) causes the degeneration of primary afferents of DRG neurons and the shedding of myelin sheaths from damaged afferents. A subset of microglia phagocyte the myelin debris and CD11c+ microglia appear in the spinal dorsal horn (SDH). These specialized CD11c+ microglia express the AXL receptor tyrosine kinase (AXL) and release IGF-1 to resolve pain.

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