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. 2022 Aug 3;12(1):13353.
doi: 10.1038/s41598-022-17632-y.

The prevalence of human papillomavirus among women in northern Guangdong Province of China

Wenbo Huang  1 , Hongyan Xu  1 , Hongbo Hu  1 , Dingmei Zhang  2 , Yulan Liu  1 , Yanle Guo  1 , Fengjin Xiao  1 , Weijuan Chen  1 , Zhanzhong Ma  3
Affiliations

The prevalence of human papillomavirus among women in northern Guangdong Province of China

Wenbo Huang et al. Sci Rep. .

Abstract

Globally, cervical cancer, whose etiologic factor is Human papillomavirus (HPV), is the third most common cancer among women. In cervical cancer screening, HPV testing is important. However, the prevalence of HPV in northern Guangdong Province has not been conclusively determined. A total of 100,994 women attending Yuebei People's Hospital Affiliated to Shantou University Medical College between 2012 and 2020 were recruited. HPV was tested by a polymerase chain reaction (PCR)-based hybridization gene chip assay. The prevalence of HPV among these women was established to be19.04%. Peak prevalence was observed in women aged 40-49 (7.29%). Besides, the prevalence of single-type HPV infection (14.46%) was significantly high, compared to multiple-type infection (4.58%) (p < 0.01), while the prevalence of high-risk HPV infection (19.97%) was significantly higher than that of low-risk genotypes (5.48%) (p < 0.01). The most prevalent high-risk genotypes were HPV52 (4.16%), HPV16 (2.98%), HPV58 (2.15%), HPV53 (1.58%) and HPV68 (1.34%). HPV co-infection with up to 10 genotypes was reported for the first time. Our findings suggested a high burden of HPV infections among women in northern Guangdong. Establishing the prevalence and genotype distribution characteristics of HPV infections in the region can contribute to cervical cancer prevention through HPV vaccination.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
HPV infection rate in different age groups.
Figure 2
Figure 2
HPV infection rate from 2012 to 2020.
Figure 3
Figure 3
Distribution of HR-HPV subtypes infection.
Figure 4
Figure 4
Distribution of LR-HPV subtypes infection.
Figure 5
Figure 5
(a) HPV positive coinfection with 10 subtypes; (b) HPV negative ybridization.
See this image and copyright information in PMC

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