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Review
. 2022 Jul 18:9:965073.
doi: 10.3389/fnut.2022.965073. eCollection 2022.

Research progress on extraction, purification, structure and biological activity of Dendrobium officinale polysaccharides

Yuan He  1 , Lin Li  2 , Hao Chang  3 , Bin Cai  4 , Huajun Gao  4 , Guoyu Chen  1 , Wen Hou  2 , Zubaydan Jappar  2 , Yizhe Yan  1
Affiliations
Review

Research progress on extraction, purification, structure and biological activity of Dendrobium officinale polysaccharides

Yuan He et al. Front Nutr. .

Abstract

Dendrobium officinale Kimura et Migo (D. officinale) is a traditional medicinal and food homologous plant that has been used for thousands of years in folk medicine and nutritious food. Recent studies have shown that polysaccharide is one of the main biologically active components in D. officinale. D. officinale polysaccharides possess several biological activities, such as anti-oxidant, heptatoprotective, immunomodulatory, gastrointestinal protection, hypoglycemic, and anti-tumor activities. In the past decade, polysaccharides have been isolated from D. officinale by physical and enzymatic methods and have been subjected to structural characterization and activity studies. Progress in extraction, purification, structural characterization, bioactivity, structure-activity relationship, and possible bioactivity mechanism of polysaccharides D. officinale were reviewed. In order to provide reference for the in-depth study of D. officinale polysaccharides and the application in functional food and biomedical research.

Keywords: Dendrobium officinale; biological activity; polysaccharides; structural characterization; structure-activity relationship.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic representation of the extraction, purification, and bioactivity of polysaccharides from Dendrobium officinale.
FIGURE 2
FIGURE 2
The chemical structure of D. officinale polysaccharides. (A) The D. huoshanense polysaccharide (HPS-1B23), (B) two component polysaccharides (DOP-1, DOP-2), (C) a novel polysaccharide (S32), (D) two novel polysaccharide fractions (DOW-1, DOPW-2).
FIGURE 3
FIGURE 3
Bioactivities of D. officinale polysaccharides.
FIGURE 4
FIGURE 4
The potential immunomodulatory mechanisms of D. officinale.
FIGURE 5
FIGURE 5
The potential anti-tumor mechanisms of D. officinale.
FIGURE 6
FIGURE 6
The potential hypoglycemic mechanisms of D. officinale.
See this image and copyright information in PMC

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