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Case Reports
. 2022 Aug;72(4):356-359.
doi: 10.1007/s13224-021-01601-y. Epub 2022 Feb 23.

Inhibin B Secreting Ovarian Fibroma

Garima Yadav  1 , Ishita Aggarwal  1 , Aasma Nalwa  2 , Binit Sureka  3
Affiliations
Case Reports

Inhibin B Secreting Ovarian Fibroma

Garima Yadav et al. J Obstet Gynaecol India. 2022 Aug.

Abstract

Background: Nearly 90% of all the hormone-producing ovarian tumours are sex cord-stromal tumours (SCSTs). The Ovarian fibroma is a hormonally inactive variant of SCST. It is composed of spindle, oval, round cells producing collagen and accounts for approximately 4% of all ovarian neoplasms. Amongst the other SCSTs, Inhibin B is an important tumour marker. It is a heterodimeric glycoprotein hormone that is secreted primarily by the granulosa cells of the developing follicles. High levels of Inhibin-B can hamper follicular recruitment, leading to amenorrhea in a reproductive age woman.

Finding: In this case report, we describe a rare case of a reproductive age female presenting with secondary amenorrhea, having an Ovarian Fibroma, producing massive amounts of Inhibin B.

Significance: Although some pathological variants of ovarian fibromas like cyst-adeno-fibroma and ovarian fibro-thecoma are known to secrete inhibin B, benign /pure ovarian fibromas rarely do so.

Keywords: FSH; Inhibin B; Ovarian fibroma; Secondary amenorrhea.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
An ovarian mass of size13 × 12x7cm with an intact capsule, smooth lobulated surface, along with left fallopian tube stretched over it. Picture also depicts the normal looking uterus and right fallopian tube and ovary
Fig. 2
Fig. 2
IHC image of the ovarian mass specimen depicting an encapsulated benign neoplasm comprising of spindle-shaped cells arranged in long fascicles and forming whorls at places, s/o ovarian fibroma. The spindle-shaped cells showed variable expression for Inhibin B (red arrow; brown colour) and were immune-negative for Caldesmon (thus, the smooth muscle nature of the neoplasm ruled out)
See this image and copyright information in PMC

References

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