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Case Reports
. 2022 Jul 21:10:54-63.
doi: 10.5414/CNCS110924. eCollection 2022.

Minimal change disease and COVID-19 vaccination: Four cases and review of literature

Preeti Chandra  1 , Marisa Roldao  2 , Cinthia Drachenberg  3 , Paulo Santos  2 , Naoki Washida  4 , Alexander Clark  5 , Bipin Bista  5 , Ryunosuke Mitsuna  4 , Angelito Yango  5
Affiliations
Case Reports

Minimal change disease and COVID-19 vaccination: Four cases and review of literature

Preeti Chandra et al. Clin Nephrol Case Stud. .

Abstract

There have been multiple reports of the development of de novo or relapse of glomerular diseases after SARS-CoV-2 vaccination. While most of them have occurred with the mRNA vaccines (Pfizer/BioNTech and Moderna/NIAID), there also have been reports associated with the vector vaccines (AstraZeneca/ChAdOx1-S) vaccine and the inactivated vaccines. Minimal change disease (MCD) is one of the more common glomerular diseases noted to have been associated with the COVID-19 vaccination. We report here 4 more cases of MCD occurring in association with the COVID-19 vaccine, 3 were de novo cases, and 1 case had a relapse of MCD. We also review all the 41 cases described thus far in the literature and review potential common pathways activated by the vaccination that play a role in the pathogenesis of MCD.

Keywords: COVID-19 vaccine; glomerular disease; graft versus host disease; minimal change disease; nephrotic syndrome.

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