Intra-renal factors in renin release
- PMID: 359238
- DOI: 10.1159/000401649
Intra-renal factors in renin release
Abstract
Renin release is believed to depend more on vasodilatation in the afferent arteriole than on any other factor. This allows for opposing effects of vasoconstriction and vasodilatation produced by sympathetic nerve stimulation by drugs or by autoregulation, to be interpreted in relation to the study of stretch of the afferent arteriole. This reduces but does not remove the necessity for alternate control through the macula densa. A final common pathway for all these stimuli is suggested through alterations in net calcium flux in the juxtaglomerular cell where increased intracellular calcium inhibits, and decreased intracellular calcium increases, renin release.
Similar articles
-
The pathophysiology of renin release in renovascular hypertension.Semin Nephrol. 2000 Sep;20(5):394-401. Semin Nephrol. 2000. PMID: 11022891 Review.
-
Mechanisms for macula densa cell release of renin.Acta Physiol Scand. 2004 Aug;181(4):471-4. doi: 10.1111/j.1365-201X.2004.01320.x. Acta Physiol Scand. 2004. PMID: 15283760 Review.
-
Role of the macula densa in renin release.Hypertension. 1985 May-Jun;7(3 Pt 2):I49-54. doi: 10.1161/01.hyp.7.3_pt_2.i49. Hypertension. 1985. PMID: 3888838
-
Effects of adenosine on renin release from isolated rat glomeruli and kidney slices.Pflugers Arch. 1985 Jul;404(3):232-7. doi: 10.1007/BF00581244. Pflugers Arch. 1985. PMID: 3898016
-
Differential roles of the sodium-calcium exchanger in renin secretion and renal vascular resistance.Pflugers Arch. 2001 Aug;442(5):693-9. doi: 10.1007/s004240100591. Pflugers Arch. 2001. PMID: 11512025
Cited by
-
Calcium dependency of the inhibitory effect of antidiuretic hormone on in vitro renin secretion in rats.J Physiol. 1981 Jun;315:21-30. doi: 10.1113/jphysiol.1981.sp013729. J Physiol. 1981. PMID: 7031229 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources