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Review
. 2022 Jul 26:15:4275-4290.
doi: 10.2147/JIR.S374117. eCollection 2022.

Research Progress on the Mechanism of Sepsis Induced Myocardial Injury

Cheng-Fei Bi #  1   2   3 , Jia Liu #  2   4 , Li-Shan Yang  1 , Jun-Fei Zhang  1   2   3
Affiliations
Review

Research Progress on the Mechanism of Sepsis Induced Myocardial Injury

Cheng-Fei Bi et al. J Inflamm Res. .

Abstract

Sepsis is an abnormal condition with multiple organ dysfunctions caused by the uncontrolled infection response and one of the major diseases that seriously hang over global human health. Besides, sepsis is characterized by high morbidity and mortality, especially in intensive care unit (ICU). Among the numerous subsequent organ injuries of sepsis, myocardial injury is one of the most common complications and the main cause of death in septic patients. To better manage septic inpatients, it is necessary to understand the specific mechanisms of sepsis induced myocardial injury (SIMI). Therefore, this review will elucidate the pathophysiology of SIMI from the following certain mechanisms: apoptosis, mitochondrial damage, autophagy, excessive inflammatory response, oxidative stress and pyroptosis, and outline current therapeutic strategies and potential approaches in SIMI.

Keywords: mechanism; sepsis induced myocardial injury; signaling pathway.

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Conflict of interest statement

The authors declare that there is no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Mechanisms of myocardial injury induced by sepsis.
Figure 2
Figure 2
Apoptosis-related proteins of SIMI.
Figure 3
Figure 3
PI3K/Ak/mTOR and AMPK pathway relating to autophagy in SIMI.
See this image and copyright information in PMC

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