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. 2022 Jul 18:10:922289.
doi: 10.3389/fpubh.2022.922289. eCollection 2022.

The Association Between Diabetic Retinopathy and the Prevalence of Age-Related Macular Degeneration-The Kailuan Eye Study

Zhang Yongpeng  1 , Wang Yaxing  2 , Zhou Jinqiong  1 , Wang Qian  1 , Yan Yanni  1 , Yang Xuan  1 , Yang Jingyan  1 , Zhou Wenjia  1 , Wang Ping  1 , Shen Chang  1 , Yang Ming  1 , Luan Yanan  1 , Wang Jinyuan  1 , Wu Shouling  3 , Chen Shuohua  4 , Wang Haiwei  5 , Fang Lijian  6 , Wan Qianqian  7 , Zhu Jingyuan  1 , Nie Zihan  1 , Chen Yuning  1 , Xie Ying  8 , Jost B Jonas  9 , Wei Wenbin  1
Affiliations

The Association Between Diabetic Retinopathy and the Prevalence of Age-Related Macular Degeneration-The Kailuan Eye Study

Zhang Yongpeng et al. Front Public Health. .

Abstract

This study aimed to investigate the prevalence of age-related macular degeneration (AMD) in patients with diabetes mellitus (DM) and diabetic retinopathy (DR) and analyze whether DR is a risk factor for AMD. This population-based epidemiological study included 14,440 people from the Kailuan Eye Study in 2016, of whom 1,618 were patients with type 2 DM aged over 50 years, and 409 had DM with DR. We analyzed whether there were differences in the prevalence of AMD between DM with DR and DM without DR, and conducted a hierarchical statistical analysis according to different stages of DR. Using variable regression analysis, we explored whether DR constituted a risk factor for AMD. In the DM population, the prevalence of wet AMD in patients with DM with and without DR was 0. 3 and 0.2%, respectively, with no significant difference (P = 0.607). Meanwhile, the prevalence of dry AMD in patients with DM with and without DR was 20.8 and 16.0%, respectively, with a significant difference. In the subgroup analysis of dry AMD, the prevalence of early, middle, and late dry AMD in DM with DR was 14.4, 5.9, and 0.5%, respectively. In DM without DR, the prevalence of early, middle, and late dry AMD was 10.5, 4.8, and 0.7%, respectively (P = 0.031). In the subgroup analysis of DR staging, statistical analysis could not be performed because of the limited number of patients with PDR. In the variable regression analysis of risk factors for dry AMD, after adjusting for age, sex, body mass index, hypertension, and dyslipidemia, DR constituted the risk factor for dry AMD. In conclusion, DM did not constitute a risk factor for AMD, and the prevalence of wet AMD and dry AMD in patients with DM and DR was higher than that in patients with DM without DR (among which dry AMD was statistically significant). Multivariate regression analysis confirmed that DR is an independent risk factor for dry AMD. Reasonable control of DM and slowing down the occurrence and development of DR may effectively reduce the prevalence of AMD in patients with DM.

Keywords: age-related macular degeneration; diabetes mellitus; diabetic retinopathy; epidemiology; prevalence.

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Conflict of interest statement

CS was employed by Kailuan Group. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of included and excluded population.
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