doi: 10.1164/arrd.1987.135.6P2.S2.
A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity?
- PMID: 3592414
- DOI: 10.1164/arrd.1987.135.6P2.S2
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A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity?
Am Rev Respir Dis.
1987 Jun.
Abstract
Paf-acether (platelet-activating factor, 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent mediator of inflammation and allergy, synthesized by various cell types. It is noteworthy that IgE-sensitized alveolar macrophages are capable of releasing this mediator which, in turn, induces a platelet-dependent, cyclooxygenase-independent acute bronchoconstriction in the guinea pig, monkey, and man. Indirect evidence suggests that this mediator may also play a role in human asthma as an inducer of bronchial hyperreactivity, but clear definition of its importance in any disease must await study of the effects of specific, selective antagonists.
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