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Review
. 2022 Jul 18:12:903800.
doi: 10.3389/fonc.2022.903800. eCollection 2022.

IL-6: The Link Between Inflammation, Immunity and Breast Cancer

Juan Chen  1 , Yanghui Wei  2 , Weiqin Yang  3 , Qingnan Huang  2 , Yong Chen  2 , Kai Zeng  2 , Jiawei Chen  2
Affiliations
Review

IL-6: The Link Between Inflammation, Immunity and Breast Cancer

Juan Chen et al. Front Oncol. .

Abstract

Breast cancer is one of the leading causes of mortality in females. Over the past decades, intensive efforts have been made to uncover the pathogenesis of breast cancer. Interleukin-6 (IL-6) is a pleiotropic factor which has a vital role in host defense immunity and acute stress. Moreover, a wide range of studies have identified the physiological and pathological roles of IL-6 in inflammation, immune and cancer. Recently, several IL-6 signaling pathway-targeted monoclonal antibodies have been developed for cancer and immune therapy. Combination of IL-6 inhibitory antibody with other pathways blockage drugs have demonstrated promising outcome in both preclinical and clinical trials. This review focuses on emerging studies on the strong linkages of IL-6/IL-6R mediated regulation of inflammation and immunity in cancer, especially in breast cancer.

Keywords: breast cancer; immune; inflammation; interleukin-6; target therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The interaction network of IL-6 and breast cancer cells/stromal cells.
See this image and copyright information in PMC

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