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. 2022 Jul 18:12:947643.
doi: 10.3389/fonc.2022.947643. eCollection 2022.

Predictors predisposing to orocutaneous fistula occurrence following free flap reconstruction

Wenlu Li  1 , Shuang Wu  1 , Junhui Yuan  2 , Fan Meng  2 , Chunmiao Xu  2 , Hailiang Li  2
Affiliations

Predictors predisposing to orocutaneous fistula occurrence following free flap reconstruction

Wenlu Li et al. Front Oncol. .

Abstract

Objectives: To explore the possible risk factors of orocutaneous fistula (OCF) development in free flap reconstruction of the tongue/floor of the mouth (TFOM).

Methods: Data of patients who underwent free flap reconstruction of the TFOM were retrospectively analyzed. The association between clinicopathologic variables and OCF occurrence was analyzed using univariate and multivariate analyses.

Results: Altogether, 469 patients were enrolled. OCF occurred in 43 patients with a rate of 9.2%. The univariate analysis revealed the negative effects of smoking, preoperative albumin level, cachexia, T4 stage, neck dissection, entire resection of the floor of the mouth (FOM), segmental mandibulectomy, and surgical site infection on OCF occurrence. The multivariate analysis confirmed the independence of cachexia (p<0.001, 4.386[1.883-9.472]), tumor stage (p<0.001, 2.738[1.482-6.629]), entire FOM resection (p<0.001, 6.332[2.110-14.432]), and surgical site infection (p<0.001, 5.376[1.998-11.218]) in affecting the OCF development.

Conclusions: OCF development following free flap reconstruction of the TFOM was relatively uncommon, but significantly associated with presence of cachexia, T4 stage, entire FOM resection, and surgical site infection.

Keywords: cachexia; floor of the mouth; free flap; orocutaneous fistula; system design; tongue.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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