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. 2022 Jul 25:2022:9722458.
doi: 10.1155/2022/9722458. eCollection 2022.

Effect of Transdermal Fentanyl Patch Combined with Enhanced Recovery after Surgery on the Curative Effect and Analgesic Effect of Liver Cancer

Hengmei Zhu  1 , Hongmei Xiao  2 , Guihua Lu  3 , Shuheng Fang  2
Affiliations

Effect of Transdermal Fentanyl Patch Combined with Enhanced Recovery after Surgery on the Curative Effect and Analgesic Effect of Liver Cancer

Hengmei Zhu et al. Biomed Res Int. .

Retraction in

Abstract

Its goal was to see how a transdermal fentanyl patch combined with accelerated recovery after surgery (ERAS) affected the treatment efficacy and analgesic effect of liver cancer, as well as to help patients with liver cancer choose the right analgesic treatment and nursing mode. 150 patients with liver cancer were divided into group A (transdermal fentanyl patch), group B (ERAS), and group C (transdermal fentanyl patch combined with ERAS). Patients in the three groups were compared in terms of pain, survival, psychological status, adverse responses, postoperative recovery, and patient satisfaction. The results showed that under different treatment and nursing methods, the number of patients with mild cancer pain in the three groups was increased, especially the number of patients with mild cancer pain in group C (P < 0.05). Besides, the quality of life score of patients in each group was decreased. Patients who received the combination analgesia had a significantly higher quality of life than those who received simply a transdermal fentanyl patch or ERAS (P < 0.05). The scores of both the Hamilton anxiety scale (HAMA) and Hamilton depression rating scale (HAMD) of patients with the combined analgesia were decreased signally (P < 0.05). There were few patients with combined analgesia who had adverse reactions (P < 0.05). After surgery, the time of the first anal exhaust, first defecation, and first ambulation in group C were shorter than those in the other two groups (P < 0.05). To summarize, combining the two techniques aided in the recovery of gastrointestinal function as well as the physical recovery of patients following surgery. Furthermore, combining the two approaches produced a clear analgesic impact, which could improve patients' quality of life while also having a favorable clinical adoption effect.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The nursing process of ERAS.
Figure 2
Figure 2
The observation indexes before and after treatment.
Figure 3
Figure 3
Comparison of the grading of cancer pain in the three groups before and after treatment. (a)–(c) The number of patients with mild cancer pain, moderate cancer pain, and severe cancer pain. Note: ∗ meant that the difference was statistically considerable before and after treatment, P < 0.05.
Figure 4
Figure 4
Comparison of quality of life scores among the three groups before and after treatment. (a)–(e) Physical well-being, psychological well-being, hardship caused by cancer, social well-being, and nausea scores. Note: ∗ meant that after treatment, compared with group A and group B, P < 0.05.
Figure 5
Figure 5
Comparison of the HAMA scores among the three groups before and after treatment. Note: ∗ meant that the difference was statistically considerable before and after treatment, P < 0.05.
Figure 6
Figure 6
Comparison of the HAMD scores among the three groups before and after treatment. Note: ∗ meant that the difference was statistically considerable before and after treatment, P < 0.05.
Figure 7
Figure 7
Comparison of adverse reactions among the three groups. (a)–(d) Constipation, vomiting, vertigo, and drowsiness). Note: ∗ compared with group A, P < 0.05.
Figure 8
Figure 8
Time of first anal exhaust after surgery in three groups. Note: ∗ compared with group A, P < 0.05.
Figure 9
Figure 9
Time of the first defecation after surgery in three groups. Note: ∗ compared with group A, P < 0.05.
Figure 10
Figure 10
Time of the first ambulation after surgery in the three groups. Note: ∗ compared with group A, P < 0.05.
Figure 11
Figure 11
Comparison of patients' satisfaction among the three groups.
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