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. 2022 Dec 1;107(12):2983-2987.
doi: 10.3324/haematol.2022.281431.

Mass spectrometry-based proteomics in clinical practice amyloid typing: state-of-the-art from a French nationwide cohort

Magali Colombat  1 , Margot Gaspard  2 , Mylène Camus  3 , Jessica Dalloux-Chioccioli  2 , Audrey Delas  2 , Elsa Poullot  4 , Anissa Moktefi  5 , Arnaud François  6 , Anne Moreau  7 , Jean-Bapiste Gibier  8 , Pierre Raynaud  9 , Antoine Huart  10 , Alexis Piedrafita  11 , Julia Gilhodes  12 , Olivier Lairez  13 , Gilles Grateau  14 , Sophie Georgin-Lavialle  14 , Hervé Maisonneuve  15 , Philippe Moreau  16 , Arnaud Jaccard  17 , Franck Bridoux  18 , Violaine Plante-Bordeneuve  19 , Thibaud Damy  20 , Hervé Mal  21 , Pierre Brousset  2 , Sophie Valleix  22 , Odile Burlet-Schiltz  3
Affiliations

Mass spectrometry-based proteomics in clinical practice amyloid typing: state-of-the-art from a French nationwide cohort

Magali Colombat et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Tissue/organ tropism and identification rate of the amyloid protein per tissue/organ. The tissue/organ distribution of the 19 amyloid types identified in the present study is illustrated in decreasing order of frequency. Among the 26 tissue/organs analyzed herein, the 5 most commonly (67.5% of cases) analyzed anatomic sites were secondary salivary glands (21.0%), heart (17.2%), lung (10.8%), gastrointestinal tract (9.4%), and kidney (9.1%). Fat aspirate/biopsy was not analyzed in this series because this procedure is not as commonly performed in France as in other countries. The diversity of the amyloid types was greater in the kidney and the heart with 10 and 6 different types identified, respectively. The amyloid protein identification rate (IR) is reported for each of the 26 tissues/organs. CNS: central nervous system; GI tract: gastrointestinal tract; PTH: parathyroid hormon.
See this image and copyright information in PMC

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