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. 2022 Dec;77(12):3684-3686.
doi: 10.1111/all.15468. Epub 2022 Aug 14.

The impact of maternal-fetal omalizumab transfer on peanut-specific responses in an ex vivo placental perfusion model

Akash Kothari  1   2 , Birgit Hirschmugl  3   4 , Jean-Soo Lee  1   2 , Birgit Pfaller  5   6 , Klara Schmidthaler  7 , Zsolt Szépfalusi  7 , Christian Wadsack  3   4 , Thomas Eiwegger  1   2   5   8
Affiliations

The impact of maternal-fetal omalizumab transfer on peanut-specific responses in an ex vivo placental perfusion model

Akash Kothari et al. Allergy. 2022 Dec.
No abstract available

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Conflict of interest statement

AK, BH, JSL, BP, KS, and CW have nothing to disclose. ZS holds advisory board roles for Nutricia/Danone, Aimmune, and Sanofi. TE reports to act as local PI for company‐sponsored trials by DBV and sub‐investigator for Regeneron, holds grants from Innovation Fund Denmark, CIHR outside the submitted work. He is Co‐Investigator or scientific lead in three investigator‐initiated oral immunotherapy trials supported by the Food Allergy and Anaphylaxis Program SickKids and serves as an associate editor for Allergy. He/his laboratory received unconditional/in‐kind contributions from Macro Array Diagnostics and an unrestricted grant from ALK. He holds advisory board roles for ALK, Nutricia/Danone, and Aimmune.

Figures

FIGURE 1
FIGURE 1
Transfer of Omalizumab and Peanut protein across the placental barrier. (A) In the human placental ex vivo model sample in‐flow (artery) and out‐flow (vein) are recorded to and from the placental tissue. (B) Omalizumab and (C) peanut extract transfer kinetics as percent change from maternal artery to fetal vein detected via ELISA.
FIGURE 2
FIGURE 2
Placental peanut allergen transfer in the context of plasma from allergic individual and omalizumab. (A) Ara h 2 concentrations (ng/ml) in fetal vein and artery samples were determined by ELISA in PE alone (dashed line, 1.03 ng/ml) and PE/PA compared to PE/PA/Oma experiments. (B) Basophil activation tests were conducted by flow cytometry to assess the functionality of transferred allergen. Activation levels are expressed as %CD63+ basophils in PE, PE/PA, and PE/PA/Oma experiments.
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