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. 2022 Oct 21;210(1):1-13.
doi: 10.1093/cei/uxac070.

British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy

S Grigoriadou  1 , R Clubbe  2 , T Garcez  3 , A Huissoon  4 , D Grosse-Kreul  5 , S Jolles  6 , K Henderson  7 , J Edmonds  3 , D Lowe  8 , C Bethune  9
Affiliations

British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy

S Grigoriadou et al. Clin Exp Immunol. .

Abstract

Currently, there is no guideline to support the use of immunoglobulin replacement therapy (IgRT) in primary and secondary immunodeficiency disorders in UK. The UK Primary Immunodeficiency Network (UK-PIN) and the British Society of Immunology (BSI) joined forces to address this need. Given the paucity of evidence, a modified Delphi approach was used covering statements for the initiation, monitoring, discontinuation of IgRT as well as home therapy programme. A group of six consultant immunologists and three nurse specialists created the statements, reviewed responses and feedback and agreed on final recommendations. This guideline includes 22 statements for initiation, 22 statements for monitoring, 11 statement for home therapy, and 19 statements for discontinuation of IgRT. Further areas of research are proposed to improve future delivery of care.

Keywords: antibodies; human; immunodeficiency disorders; immunoglobulin.

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Conflict of interest statement

The authors have no financial conflicts of interest.

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