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Case Reports
. 2022 Sep;28(9):1920-1923.
doi: 10.3201/eid2809.220875. Epub 2022 Aug 4.

Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

Bas B Oude Munnink, Roel H T Nijhuis, Nathalie Worp, Marjan Boter, Babette Weller, Babs E Verstrepen, Corine GeurtsvanKessel, Maarten F Corsten, Anne Russcher, Marion Koopmans
Case Reports

Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

Bas B Oude Munnink et al. Emerg Infect Dis. 2022 Sep.

Abstract

We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

Keywords: Alpha variant; COVID-19; SARS-CoV-2; coronavirus disease; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; the Netherlands; variants; virus evolution; viruses; zoonoses.

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Figures

Figure
Figure
Phylogenetic analysis of all downsampled SARS-CoV-2 Alpha variants (B.1.1.7) in the Netherlands. Scale bar indicates number of substitutions per site.
See this image and copyright information in PMC

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