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Review
. 2022 Aug;63(8):840-850.
doi: 10.1007/s00108-022-01368-y. Epub 2022 Jul 7.

[The value of COVID-19 vaccination in the context of Long-COVID]

[Article in German]
Stilla Bauernfeind  1 , Barbara Schmidt  2
Affiliations
Review

[The value of COVID-19 vaccination in the context of Long-COVID]

[Article in German]
Stilla Bauernfeind et al. Inn Med (Heidelb). 2022 Aug.

Abstract
in English, German

There are currently no strategies available on how to deal with Long-COVID (COVID "coronavirus disease"). COVID-19 vaccination could be both a preemptive and a therapeutic option for the future. The evaluation of the available studies is complicated by varying definitions. There are, however, indications that (complete) COVID-19 vaccination is able not only to prevent symptomatic infection but also to reduce the risk of Long-COVID. In some patients with Long-COVID, symptoms are modified after (first and/or second) COVID-19 vaccination; however, there is no clear evidence for a real therapeutic effect on Long-COVID.

Strategien zum Umgang mit Long-COVID (COVID „coronavirus disease“) sind bislang nicht verfügbar. Eine der aktuell geprüften Optionen ist die COVID-19-Impfung, sowohl präventiv als auch therapeutisch. Die Bewertung der vorhandenen Studien ist durch uneinheitliche Definitionen erschwert. Es gibt jedoch Hinweise, dass die (vollständige) COVID-19-Impfung nicht nur die symptomatische Infektion verhindern kann, sondern auch das Risiko für Long-COVID bei Durchbruchinfektionen zu reduzieren vermag. Bei Patienten mit Long-COVID führt die anschließende (einfache und/oder zweifache) COVID-19-Impfung teilweise zu einer Symptommodifikation, die bisweilen nur passager ist. Ein therapeutischer Effekt kann aus der vorliegenden Evidenz allerdings nicht sicher abgeleitet werden.

Keywords: Breakthrough infection; COVID-19 vaccination; Long COVID/prevention; Long COVID/therapy; „Severe acute respiratory syndrome coronavirus type 2“ (SARS-CoV-2).

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References

    1. World Health Organization (2021) A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021. https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_cond.... Zugegriffen: 29. Apr. 2022
    1. National Institute for Health and Care Excellence (NICE) (2020) Scottish intercollegiate guidelines network (SIGN) and royal college of general practitioners (RCGP). COVID-19 rapid guideline: managing the long-term effects of COVID-19. https://www.nice.org.uk/guidance/ng188/resources/covid19-rapid-guideline.... Zugegriffen: 29. Apr. 2022
    1. Koczulla AR, Ankermann T, Behrends U, Berlit P, Böing S, Brinkmann F, Franke C, Glöckl R, Gogoll C, Hummel T, Kronsbein J, Maibaum T, Peters EMJ, Pfeifer M, Platz T, Pletz M, Pongratz G, Powitz F, Rabe KF, Scheibenbogen C, Stallmach A, Stegbauer M, Wagner HO, Waller C, Wirtz H, Zeiher A, Zwick R (2021) S1-Leitlinie Post-COVID/Long-COVID. https://www.awmf.org/uploads/tx_szleitlinien/020-027l_S1_Post_COVID_Long.... Zugegriffen: 30. Apr. 2021
    1. Harrison S, Walters B, Simmons Z, Cook M, Clark R (2022) The effectiveness of vaccination against long COVID; A rapid evidence briefing. https://ukhsa.koha-ptfs.co.uk/cgi-bin/koha/opac-retrieve-file.pl?id=fe4f.... Zugegriffen: 23. Apr. 2022
    1. The Public Health Agency of Canada (2022) Are there clinically significant interactions between COVID-19 vaccination and post-COVID-19 condition (long COVID)? https://www.canada.ca/content/dam/phac-aspc/documents/services/diseases/.... Zugegriffen: 23. Apr. 2022

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