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Review
. 2022 Jul 4;19(8):1216-1226.
doi: 10.7150/ijms.74137. eCollection 2022.

Role of extracellular vesicles in osteosarcoma

Qifan Yang  1 , Jing Liu  2 , Bo Wu  1 , Xinyu Wang  1 , Ye Jiang  1 , Dong Zhu  1
Affiliations
Review

Role of extracellular vesicles in osteosarcoma

Qifan Yang et al. Int J Med Sci. .

Abstract

Osteosarcoma is a malignant bone tumor characterized by the direct production of osteoid tissue from tumor cells. Extracellular vesicles are membranous vesicles released by cells into the extracellular matrix, which exist widely in various body fluids and cell supernatants, and stably carry some important signaling molecules. They are involved in cell communication, cell migration, angiogenesis and tumor cell growth. Increasing evidence has shown that extracellular vesicles play a significant role in osteosarcoma development, progression, and metastatic process, indicating that extracellular vesicles can be use as biomarker vehicles in the diagnosis and prognosis of osteosarcoma. This review discusses the basic biological characteristics of extracellular vesicles and focuses on their application in osteosarcoma.

Keywords: chemotherapy resistance; extracellular vesicles; immune escape; microenvironment; osteosarcoma.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Types of extracellular vesicle (EV). Based on the biogenesis, diameter and biophysical properties, EV can be divided into three subgroups: a. Apoptotic body; b. Microvesicles and c. Exosomes.
Figure 2
Figure 2
Extracellular vesicles (EVs) in osteosarcoma (OS). The role of EVs in OS includes regulating OS metastasis, tumor microenvironment, immune escape, chemotherapy resistance, which make them to become promising biomarkers and therapeutic targets for OS.
See this image and copyright information in PMC

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