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Review
. 2022 Jul 19:12:963617.
doi: 10.3389/fonc.2022.963617. eCollection 2022.

The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression

Lu Xia  1 , Jingyun Chen  1 , Min Huang  1 , Jie Mei  1 , Min Lin  1
Affiliations
Review

The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression

Lu Xia et al. Front Oncol. .

Abstract

Accumulated evidence has revealed that F-box protein, a subunit of SCF E3 ubiquitin ligase complexes, participates in carcinogenesis and tumor progression via targeting its substrates for ubiquitination and degradation. F-box proteins could be regulated by cellular signaling pathways and noncoding RNAs in tumorigenesis. Long noncoding RNA (lncRNA), one type of noncoding RNAs, has been identified to modulate the expression of F-box proteins and contribute to oncogenesis. In this review, we summarize the role and mechanisms of multiple lncRNAs in regulating F-box proteins in tumorigenesis, including lncRNAs SLC7A11-AS1, MT1JP, TUG1, FER1L4, TTN-AS1, CASC2, MALAT1, TINCR, PCGEM1, linc01436, linc00494, GATA6-AS1, and ODIR1. Moreover, we discuss that targeting these lncRNAs could be helpful for treating cancer via modulating F-box protein expression. We hope our review can stimulate the research on exploration of molecular insight into how F-box proteins are governed in carcinogenesis. Therefore, modulation of lncRNAs is a potential therapeutic strategy for cancer therapy via regulation of F-box proteins.

Keywords: F-box protein; cancer; lncRNAs; noncoding RNA; oncogenesis; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Multiple lncRNAs regulate the expression of FBXW7 in human cancer. Multiple lncRNAs, including MT1JP, FER1L4, TTN-AS1, CASC2 and MALAT1, have been demonstrated to regulate the expression of FBXW7 in tumorigenesis.
Figure 2
Figure 2
Multiple lncRNAs regulate the expression of F-box proteins in human cancer. Multiple lncRNAs, including SLC7A11-AS1, MALAT1, PCGEM1, linc01436, linc00494 and GATA6-AS1, regulate the expression of several F-box proteins in tumorigenesis.
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