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Review
. 2022 Jul;10(3):135-143.
doi: 10.14791/btrt.2022.0010.

Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments

Jaehyun Ahn #  1 , Christopher Shin #  1 , Yeo Song Kim  2 , Jae-Sung Park  2 , Sin-Soo Jeun  2 , Stephen Ahn  3
Affiliations
Review

Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments

Jaehyun Ahn et al. Brain Tumor Res Treat. 2022 Jul.

Abstract

Over the last two decades, numerous studies have investigated the presence of human cytomegalovirus (CMV) within glioblastoma or gliomas; however, the results are severely conflicting. While a few researchers have suggested the potential benefits of cytotoxic T lymphocyte or dendritic cell-based vaccines for recurrent or newly diagnosed glioblastoma patients, several studies did not at all agree with the existence of CMV in glioblastoma cells. In this review, we summarized the conflicting results and issues about the detection of CMV in glioblastoma or glioma patients. We also provided the clinical data of published and unpublished clinical trials using CMV-specific immunotherapy for glioblastomas.

Keywords: Adoptive cell transfer; Cancer vaccines; Cytomegalovirus; Glioblastoma; Immunotherapy.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

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