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Review
. 2022 Jul;10(3):135-143.
doi: 10.14791/btrt.2022.0010.

Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments

Jaehyun Ahn #  1 , Christopher Shin #  1 , Yeo Song Kim  2 , Jae-Sung Park  2 , Sin-Soo Jeun  2 , Stephen Ahn  3
Affiliations
Review

Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments

Jaehyun Ahn et al. Brain Tumor Res Treat. 2022 Jul.

Abstract

Over the last two decades, numerous studies have investigated the presence of human cytomegalovirus (CMV) within glioblastoma or gliomas; however, the results are severely conflicting. While a few researchers have suggested the potential benefits of cytotoxic T lymphocyte or dendritic cell-based vaccines for recurrent or newly diagnosed glioblastoma patients, several studies did not at all agree with the existence of CMV in glioblastoma cells. In this review, we summarized the conflicting results and issues about the detection of CMV in glioblastoma or glioma patients. We also provided the clinical data of published and unpublished clinical trials using CMV-specific immunotherapy for glioblastomas.

Keywords: Adoptive cell transfer; Cancer vaccines; Cytomegalovirus; Glioblastoma; Immunotherapy.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

References

    1. Lau SK, Chen YY, Chen WG, Diamond DJ, Mamelak AN, Zaia JA, et al. Lack of association of cytomegalovirus with human brain tumors. Mod Pathol. 2005;18:838–843. - PubMed
    1. Poltermann S, Schlehofer B, Steindorf K, Schnitzler P, Geletneky K, Schlehofer JR. Lack of association of herpesviruses with brain tumors. J Neurovirol. 2006;12:90–99. - PubMed
    1. Khoury JD, Tannir NM, Williams MD, Chen Y, Yao H, Zhang J, et al. Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq. J Virol. 2013;87:8916–8926. - PMC - PubMed
    1. Tang KW, Alaei-Mahabadi B, Samuelsson T, Lindh M, Larsson E. The landscape of viral expression and host gene fusion and adaptation in human cancer. Nat Commun. 2013;4:2513. - PMC - PubMed
    1. Cimino PJ, Zhao G, Wang D, Sehn JK, Lewis JS, Jr, Duncavage EJ. Detection of viral pathogens in high grade gliomas from unmapped next-generation sequencing data. Exp Mol Pathol. 2014;96:310–315. - PubMed