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Editorial
. 2022 Aug 5;12(8):1844-1846.
doi: 10.1158/2159-8290.CD-22-0614.

BCL10 Mutants: Architects of Oncogenic Signaling Provide a Blueprint for Precision Medicine

James D Phelan  1 , Thomas Oellerich  2   3   4
Affiliations
Editorial

BCL10 Mutants: Architects of Oncogenic Signaling Provide a Blueprint for Precision Medicine

James D Phelan et al. Cancer Discov. .

Abstract

BCL10, a key activator of NF-κB downstream of oncogenic B-cell receptor signaling, is mutated in nearly 40% of the BN2/C1 genetic subtype of diffuse large B-cell lymphoma, but how these mutations function to augment signaling and their relevance to targeted precision medicine agents remains unclear. In this issue of Cancer Discovery, Xia and colleagues demonstrate distinct mechanisms of oncogenic signaling regulation and therapeutic vulnerabilities among different recurrent BCL10 mutations. See related article by Xia et al., p. 1922 (1).

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  • BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
    Xia M, David L, Teater M, Gutierrez J, Wang X, Meydan C, Lytle A, Slack GW, Scott DW, Morin RD, Onder O, Elenitoba-Johnson KSJ, Zamponi N, Cerchietti L, Lu T, Philippar U, Fontan L, Wu H, Melnick AM. Xia M, et al. Cancer Discov. 2022 Aug 5;12(8):1922-1941. doi: 10.1158/2159-8290.CD-21-1566. Cancer Discov. 2022. PMID: 35658124 Free PMC article.

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