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Review
. 2023 Feb;12(3):2187-2198.
doi: 10.1002/cam4.5112. Epub 2022 Aug 5.

Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fields

Mengqian Huang  1 , Parker Li  2 , Feng Chen  1 , Zehao Cai  1 , Shoubo Yang  1 , Xiaohong Zheng  1 , Wenbin Li  1
Affiliations
Review

Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fields

Mengqian Huang et al. Cancer Med. 2023 Feb.

Abstract

Gliomas refer to a group of complicated human brain tumors with a low 5-year survival rate and limited therapeutic options. Extremely low-frequency pulsed electromagnetic field (ELF-PEMF) is a specific magnetic field featuring almost no side effects. However, the application of ELF-PEMF in the treatment of gliomas is rare. This review summarizes five significant underlying mechanisms including calcium ions, autophagy, apoptosis, angiogenesis, and reactive oxygen species, and applications of ELF-PEMF in glioma treatment from a clinical practice perspective. In addition, the prospects of ELF-PEMF in combination with conventional therapy for the treatment of gliomas are reviewed. This review benefits any specialists, especially oncologists, interested in this new therapy because it can help treat patients with gliomas properly.

Keywords: electromagnetic therapy; extremely low frequency pulsed electromagnetic fields; gliomas; tumor-specific frequencies.

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Conflict of interest statement

The authors have no conflicts of interest to report.

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References

    1. Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz‐Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013–2017. Neuro Oncol. 2020;22(12 Suppl 2):iv1‐iv96. doi:10.1093/neuonc/noaa200 - DOI - PMC - PubMed
    1. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987‐996. doi:10.1056/NEJMoa043330 - DOI - PubMed
    1. Tamimi AF, Juweid M. Epidemiology and Outcome of Glioblastoma. In: De Vleeschouwer S, eds. Glioblastoma. Codon Publications. Copyright: The Authors.; 2017. - PubMed
    1. Zhan C, Lu W. The blood‐brain/tumor barriers: challenges and chances for malignant gliomas targeted drug delivery. Curr Pharm Biotechnol. 2012;13(12):2380‐2387. doi:10.2174/138920112803341798 - DOI - PubMed
    1. Bradshaw A, Wickremsekera A, Tan ST, Peng L, Davis PF, Itinteang T. Cancer stem cell hierarchy in glioblastoma multiforme. Front Surg. 2016;3:21. doi:10.3389/fsurg.2016.00021 - DOI - PMC - PubMed

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