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. 1987;95(1-2):17-28.
doi: 10.1007/BF01311331.

Non-infectious morphologically altered nucleocapsids of measles virus from persistently infected cells

O G Andzhaparidze, N M Chaplygina, N N Bogomolova, V D Lotte, I B Koptyaeva, Boriskin YuS

Non-infectious morphologically altered nucleocapsids of measles virus from persistently infected cells

O G Andzhaparidze et al. Arch Virol. 1987.

Abstract

Persistent measles virus infection of human HEp-2 or L-41 cells was accompanied by pronounced structural and functional changes of isolated intracellular viral nucleocapsids (NCs). The bulk of persistent NCs possessed altered conformation and a "string-of-beads" appearance, contained substantial amounts of subgenomic size RNAs, exhibited reduced transcriptase activity in vitro and lacked infectivity on transfection of susceptible cells. Immunogold staining revealed negligible binding of anti-P protein monoclonal antibodies to the "string-of-beads" type NCs, thus suggesting their non-functional state.

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