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Review
. 2023 Feb:89:101107.
doi: 10.1016/j.mam.2022.101107. Epub 2022 Aug 2.

Human colonic catabolism of dietary flavan-3-ol bioactives

Giuseppe Di Pede  1 , Pedro Mena  2 , Letizia Bresciani  1 , Tahani M Almutairi  3 , Daniele Del Rio  2 , Michael N Clifford  4 , Alan Crozier  5
Affiliations
Free article
Review

Human colonic catabolism of dietary flavan-3-ol bioactives

Giuseppe Di Pede et al. Mol Aspects Med. 2023 Feb.
Free article

Abstract

Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.

Keywords: Colonic catabolic and phase II metabolism; Flavan-3-ols; Procyanidins; Theaflavins; [2–(14)C](−)-Epicatechin.

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