Engineering gold nanoparticles for molecular diagnostics and biosensing
- PMID: 35932114
- DOI: 10.1002/wnan.1836
Engineering gold nanoparticles for molecular diagnostics and biosensing
Abstract
Advances in nanotechnology and medical science have spurred the development of engineered nanomaterials and nanoparticles with particular focus on their applications in biomedicine. In particular, gold nanoparticles (AuNPs) have been the focus of great interest, due to their exquisite intrinsic properties, such as ease of synthesis and surface functionalization, tunable size and shape, lack of acute toxicity and favorable optical, electronic, and physicochemical features, which possess great value for application in biodetection and diagnostics purposes, including molecular sensing, photoimaging, and application under the form of portable and simple biosensors (e.g., lateral flow immunoassays that have been extensively exploited during the current COVID-19 pandemic). We shall discuss the main properties of AuNPs, their synthesis and conjugation to biorecognition moieties, and the current trends in sensing and detection in biomedicine and diagnostics. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.
Keywords: biodetection; bioimaging; diagnostics; gold nanoparticles; nanomedicine.
© 2022 Wiley Periodicals LLC.
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References
REFERENCES
-
- Akshaya, K., Arthi, C., Pavithra, A. J., Poovizhi, P., Antinate, S. S., Hikku, G. S., Jeyasubramanian, K., & Murugesan, R. (2020). Bioconjugated gold nanoparticles as an efficient colorimetric sensor for cancer diagnostics. Photodiagnosis and Photodynamic Therapy, 30, 101699. https://doi.org/10.1016/j.pdpdt.2020.101699
-
- Albanese, A., & Chan, W. C. W. (2011). Effect of gold nanoparticle aggregation on cell uptake and toxicity. ACS Nano, 5(7), 5478-5489. https://doi.org/10.1021/nn2007496
-
- Amina, S. J., & Guo, B. (2020). A review on the synthesis and functionalization of gold nanoparticles as a drug delivery vehicle. International Journal of Nanomedicine, 15, 9823-9857. https://doi.org/10.2147/IJN.S279094
-
- An, J. H., El-Said, W. A., Yea, C. H., Kim, T. H., & Choi, J. W. (2011). Surface-enhanced Raman scattering of dopamine on self-assembled gold nanoparticles. Journal of Nanoscience and Nanotechnology, 11(5), 4424-4429. https://doi.org/10.1166/jnn.2011.3688
-
- Anselmo, A. C., & Mitragotri, S. (2016). Nanoparticles in the clinic. Bioengineering & Translational Medicine, 1(1), 10-29. https://doi.org/10.1002/btm2.10003
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