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. 2022 Aug 6;17(1):377.
doi: 10.1186/s13018-022-03253-8.

Characteristics and complications of fracture in older adults with chronic kidney disease: a cross-sectional study

Yao Meng #  1 , Mingming Fu #  1 , Junfei Guo  2 , Zhiqian Wang  3 , Yingze Zhang  4   5   6 , Zhiyong Hou  2   7
Affiliations

Characteristics and complications of fracture in older adults with chronic kidney disease: a cross-sectional study

Yao Meng et al. J Orthop Surg Res. .

Abstract

Background: The aim of this study was to analyze the clinical characteristics of older fracture patients with chronic kidney disease (CKD) and to determine the risk factors of perioperative cardiovascular complications.

Methods: We retrospectively reviewed clinical data of older fracture patients with CKD admitted to the Third Hospital of Hebei Medical University from January 2016 to October 2021. The data we collected included baseline characteristics and complications. We finally determined the risk factors of perioperative cardiovascular complications by using logistic regression.

Results: We ended up enrolling 224 patients, and there were 91 (40.6%) males and 133 (59.4%) females, with a median age of 79 years. 80-84 years old was the age group with high incidence of fracture. The majority of fracture occurred indoors (130 cases, 58.0%) and morning (98 cases, 43.8%). Hip fracture was most common (183 cases, 81.7%), of which femoral neck fracture (101 cases, 45.0%) was the most prevalent. The most common comorbid condition was hypertension (171 cases, 76.3%), and anemia was the most common complication (148 cases, 66.1%). Age ≥ 80 years (OR = 2.023, 95% CI 1.110-3.688), previously combined with cardiovascular calcification (OR = 1.901, 95% CI 1.047-3.451) and admission hemoglobin level < 100 g/L (OR = 3.191, 95% CI 1.744-5.838) were independent risk factors of perioperative cardiovascular disease (CVD).

Conclusion: It was especially necessary to enhance fracture prevention for CKD. Patients whose age older than 80, hemoglobin less than 100 g/L on admission and have previous cardiovascular calcification are more likely to develop perioperative CVD. Such patients require reasonable decisions during the perioperative period to avoid the occurrence of CVD.

Keywords: Cardiovascular calcification; Chronic kidney disease; Fracture; Hemoglobin; Older adults.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Fig. 1
Fig. 1
Composition of age and history of dialysis in elderly patients with CKD and fracture
See this image and copyright information in PMC

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References

    1. Boe DM, Boule LA, Kovacs EJ. Innate immune responses in the ageing lung. Clin Exp Immunol. 2017;187(1):16–25. doi: 10.1111/cei.12881. - DOI - PMC - PubMed
    1. Bowling CB, Plantinga L, Phillips LS, McClellan W, Echt K, Chumbler N, et al. Association of multimorbidity with mortality and healthcare utilization in chronic kidney disease. J Am Geriatr Soc. 2017;65(4):704–711. doi: 10.1111/jgs.14662. - DOI - PubMed
    1. Li C, Chen XM, Li Y, Zhou YL, Yan JN, Du XG. Factors and outcome of renal osteodystrophy-associated initial fragility fracture in end-stage renal disease patients. Kidney Dis (Basel) 2019;5(2):118–125. doi: 10.1159/000494924. - DOI - PMC - PubMed
    1. Xie L, Hu X, Li W, Ouyang Z. A retrospective study of end-stage kidney disease patients on maintenance hemodialysis with renal osteodystrophy-associated fragility fractures. BMC Nephrol. 2021;22(1):23. doi: 10.1186/s12882-020-02224-7. - DOI - PMC - PubMed
    1. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl. 2009(113):S1–130. - PubMed