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. 1987 May 29;145(1):408-14.
doi: 10.1016/0006-291x(87)91337-4.

The action of lipoxin-A on glomerular microcirculatory dynamics in the rat

K F Badr, C N Serhan, K C Nicolaou, B Samuelsson

The action of lipoxin-A on glomerular microcirculatory dynamics in the rat

K F Badr et al. Biochem Biophys Res Commun. .

Erratum in

  • Biochem Biophys Res Commun 1987 Sep 30;147(3):1300

Abstract

Intrarenal administration of 750 ng/kg/min of LX-A in euvolemic rats resulted in significant increases in single nephron GFR (38.4 +/- 1.7 to 45.5 +/- 3.0 nl/min) and plasma flow rate (95 +/- 6 to 127 +/- 9 nl/min). The latter was due to a dramatic fall in afferent arteriolar resistance. Mean transcapillary hydraulic pressure difference increased from 33 +/- 1 to 43 +/- 3 mmHg (p less than 0.05) and the glomerular capillary ultrafiltration coefficient fell from 0.060 +/- 0.013 to 0.033 +/- 0.005 nl/(s X mmHg) (p less than 0.05). These responses to LXA in the renal microcirculation are in sharp contrast to those previously observed for the leukotrienes, and thus may represent the first example of counterregulatory (constrictor/dilator) vascular interactions within the lipoxygenase pathways.

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