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Meta-Analysis
. 2022 Dec;41(12):3769-3776.
doi: 10.1007/s10067-022-06326-5. Epub 2022 Aug 6.

Intima media thickness of carotid arteries in familial Mediterranean fever: a systematic review and meta-analysis

Mira Merashli  1 , Tommaso Bucci  2 , Daniele Pastori  3 , Pasquale Pignatelli  3 , Paul R J Ames  4   5
Affiliations
Meta-Analysis

Intima media thickness of carotid arteries in familial Mediterranean fever: a systematic review and meta-analysis

Mira Merashli et al. Clin Rheumatol. 2022 Dec.

Abstract

Aim: To perform a systematic review and meta-analysis of studies reporting data on atherosclerosis and inflammatory markers in familial Mediterranean fever (FMF).

Methods: EMBASE and PubMed databases were screened according to PRISMA guidelines from inception to January 2022 for articles reporting measurements of the intima media thickness (IMT) of carotid arteries and eventually carotid plaques; random effect meta-analyses for continuous outcomes and Peto's odds ratio for rare events were employed.

Results: The screening and selection search strategy yielded 18 case controls studies (16 full papers and 2 abstracts); the IMT was greater in FMF (n = 1112) than in controls (n = 901) (p < 0.0001) with wide heterogeneity (I2 = 86.4%); a sensitivity analysis according to mean age of participants, male to female ratio, disease duration, C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen (FNG), atherogenic index of plasma (AIP), colchicine use and NOQAS revealed that the heterogeneity variance was partly explained by CRP (p = 0.01) and to a much lesser extent by the AIP (p = 0.10). The pooled prevalence of carotid plaques was greater in FMF (n = 137) than in controls (n = 156) (19% vs 8.3%, p = 0.02) with low heterogeneity.

Conclusion: FMF is characterised by premature atherosclerosis expressed as a thicker intima media and a greater prevalence of carotid plaques, partially related to the C-reactive protein, as expected by the autoinflammatory nature of FMF. Key Points • Familial Mediterranean fever is characterised by premature atherosclerosis. • C-reactive protein relates to intima media thickness in keeping with the autoinflammatory nature Familial Mediterranean fever. • Targeting the inter-critical low-grade inflammation may be relevant to minimise the additional cardiovascular risk posed by premature atherosclerosis.

Keywords: Atherosclerosis; Familial Mediterranean fever; Intima media thickness.

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References

    1. Egeli BH, Ugurlu S (2020) Familial Mediterranean fever: clinical state of the art. QJM 20:hcaa291 - DOI
    1. Schnappauf O, Chae JJ, Kastner DL, Aksentijevich I (2019) The pyrin inflammasome in health and disease. Front Immunol 10:1745 - PubMed - PMC - DOI
    1. Korkmaz C, Ozdogan H, Kasapçopur O, Yazici H (2002) Acute phase response in familial Mediterranean fever. Ann Rheum Dis 61:79–81 - PubMed - PMC - DOI
    1. Guzel S, Andican G, Seven A et al (2012) Acute phase response and oxidative stress status in familial Mediterranean fever (FMF). Mod Rheumatol 22:431–437 - PubMed - DOI
    1. Alesh MB, Barlak Keti D, Paç Kisaarslan A, Muhtaroğlu S, Taşkin SN (2022) Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status. Turk J Med Sci 52;67–75

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