Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov:67:104068.
doi: 10.1016/j.msard.2022.104068. Epub 2022 Jul 22.

MR imaging in children with transverse myelitis and acquired demyelinating syndromes

Ines El Naggar  1 , Robert Cleaveland  2 , Eva-Maria Wendel  3 , Annikki Bertolini  1 , Kathrin Schanda  4 , Michael Karenfort  5 , Charlotte Thiels  6 , Adela Della Marina  7 , Mareike Schimmel  8 , Steffen Leiz  9 , Christian Lechner  10 , Matthias Baumann  10 , Markus Reindl  4 , Andreas Wegener-Panzer  2 , Kevin Rostásy  11 ; on-behalf-of-the-BIOMARKER-Study-Group
Collaborators, Affiliations

MR imaging in children with transverse myelitis and acquired demyelinating syndromes

Ines El Naggar et al. Mult Scler Relat Disord. 2022 Nov.

Abstract

Background: Transverse myelitis (TM) occurs isolated or within other acquired demyelinating syndromes (ADS) such as neuromyelitis optica spectrum disorders (NMOSD), multiple sclerosis (MS) or myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD).

Objective: To describe and compare clinical and MRI features of children with ADS presenting with TM grouped according to antibody status and diagnosis of MS and NMOSD.

Patients and methods: Children with TM, radiological involvement of the myelon, MOG and aquaporin-4 antibody status were elegible.

Results: 100 children were identified and divided into MOGAD (n=33), NMOSD (n=7), double seronegative TM (n=34), and MS (n=26). MOGAD children had mainly acute disseminated encephalomyelitis + TM/ longitudinally extensive TM (LETM) (42%) or isolated LETM (30%). In MOGAD, LETM was present in more than half of all children (55%) with predominant involvement of only the grey matter (73%). Leptomeningeal enhancement was highly predictive of MOGAD (16/30; p=0.003). In MS patients spinal MRI showed single (50%) or multiple short lesions (46%) with involvement of grey and white matter (68%). Double seronegative children presented with LETM (74%) and brain lesions were less frequent compared to the other groups (30%).

Conclusion: Children with ADS presenting with TM reveal important radiological differences such as LETM with predominant involvement of spinal grey matter and leptomeningeal enhancement in MOGAD.

Keywords: Acquired Demyelinating Syndrome; MOG; Neuroinflammation; Paediatric; Radiologic; Transverse Myelitis.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest IN, RC, EW, ABe, KS, CTh, ADM, MSch, SL, AWP, NB, BB, SB, MBl, ABl, CC, KD, ME, AE, WF, TG, AH, KH, JK, BK, MN, DP, MP, MSa, TS, SS, JS, GW report no conflict of interest. Michael Karenfort served as consultant for Novartis. Christian Lechner has received compensation for consulting services from Roche. Matthias Baumann has received compensation for consulting services from Sanofi. Markus Reindl was supported by a research support from Euroimmun and Roche. The University Hospital and Medical University of Innsbruck (Austria, employer of Dr. Reindl) receive payments for antibody assays (MOG-, AQP4-, and other autoantibodies) and for MOG-and AQP4-antibody validation experiments organised by Euroimmun (Lübeck, Germany). Kevin Rostásy served as a consultant for the PARADIGM-Study/Novartis without payment and received honoraria for lectures given for MERCK. Andrea Klein did advisory activities for Novartis Gene Therapies, Biogen, Pfizer, Roche, Sarepta and Santhera and received speakers honoraria from Biogen, Roche, Sarepta and Santhera.

LinkOut - more resources