Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct:24:101503.
doi: 10.1016/j.tranon.2022.101503. Epub 2022 Aug 4.

Concise review: Cancer cell reprogramming and therapeutic implications

Xue Xiao  1 , Hua Chen  2 , Lili Yang  1 , Guoping Xie  3 , Risa Shimuzu  4 , Akiko Murai  5
Affiliations

Concise review: Cancer cell reprogramming and therapeutic implications

Xue Xiao et al. Transl Oncol. 2022 Oct.

Abstract

The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem cells and is considered to apply to a variety of cancers. Additionally, cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth and proliferation. Further, microRNAs (miRNAs) are found to be involved in acquisition of stem cell-like properties, regulation and reprogramming of cancer cells during cancer progression through its post-transcriptional-regulatory activity. In this concise review, we aim to integrate the current knowledge and recent advances to elucidate the mechanisms involved in the regulation of cell reprogramming and highlights the potential therapeutic implications for the future.

Keywords: CSC; Cancer cell reprogramming; Metabolic reprogramming; miRNA.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
A simplified overview of cancer cells reprogramming into CSCs, metabolic reprogramming and miRNA mediated cancer cell reprogramming.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105–111. doi: 10.1038/35102167. - DOI - PubMed
    1. Lin X., Xiao Z., Chen T., Liang S.H., Guo H. Glucose metabolism on tumor plasticity, diagnosis, and treatment. Front. Oncol. 2020;10:317. doi: 10.3389/fonc.2020.00317. - DOI - PMC - PubMed
    1. Li H., Feng Z., He M.L. Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells. Theranostics. 2020;10(16):7053–7069. doi: 10.7150/thno.41388. - DOI - PMC - PubMed
    1. Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843–854. doi: 10.1016/0092-8674(93)90529-y. - DOI - PubMed
    1. Mansoori B., Sandoghchian Shotorbani S., Baradaran B. RNA interference and its role in cancer therapy. Adv. Pharm. Bull. 2014;4(4):313–321. doi: 10.5681/apb.2014.046. - DOI - PMC - PubMed