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Review
. 2022 Jul 22:15:910543.
doi: 10.3389/fnmol.2022.910543. eCollection 2022.

Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma

Hao Wu  1   2 , Min Wei  1   2 , Yuping Li  2 , Qiang Ma  2 , Hengzhu Zhang  1   2
Affiliations
Review

Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma

Hao Wu et al. Front Mol Neurosci. .

Abstract

As is known to all, glioma, a global difficult problem, has a high malignant degree, high recurrence rate and poor prognosis. We analyzed and summarized signal pathway of the Hippo/YAP, PI3K/AKT/mTOR, miRNA, WNT/β-catenin, Notch, Hedgehog, TGF-β, TCS/mTORC1 signal pathway, JAK/STAT signal pathway, MAPK signaling pathway, the relationship between BBB and signal pathways and the mechanism of key enzymes in glioma. It is concluded that Yap1 inhibitor may become an effective target for the treatment of glioma in the near future through efforts of generation after generation. Inhibiting PI3K/Akt/mTOR, Shh, Wnt/β-Catenin, and HIF-1α can reduce the migration ability and drug resistance of tumor cells to improve the prognosis of glioma. The analysis shows that Notch1 and Sox2 have a positive feedback regulation mechanism, and Notch4 predicts the malignant degree of glioma. In this way, notch cannot only be treated for glioma stem cells in clinic, but also be used as an evaluation index to evaluate the prognosis, and provide an exploratory attempt for the direction of glioma treatment. MiRNA plays an important role in diagnosis, and in the treatment of glioma, VPS25, KCNQ1OT1, KB-1460A1.5, and CKAP4 are promising prognostic indicators and a potential therapeutic targets for glioma, meanwhile, Rheb is also a potent activator of Signaling cross-talk etc. It is believed that these studies will help us to have a deeper understanding of glioma, so that we will find new and better treatment schemes to gradually conquer the problem of glioma.

Keywords: gene expression; glioma; neoplastic; prognosis; signal pathway.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Hippo/YAP signal pathway.
FIGURE 2
FIGURE 2
The mechanism of PI3K/AKT/mTOR signaling pathway in glioma.
FIGURE 3
FIGURE 3
TSC-mTORC1 signaling pathway.
FIGURE 4
FIGURE 4
Interaction of miRNA and lncRNA in glioma.
FIGURE 5
FIGURE 5
HGF/MET signal pathway.
FIGURE 6
FIGURE 6
On/OFF WNT/β-catenin signal pathway.
FIGURE 7
FIGURE 7
He regulatory mechanism of notch in giloma.
FIGURE 8
FIGURE 8
Hedgehog signal pathway.
FIGURE 9
FIGURE 9
TGF-β signal pathway. TGF-β pathway interacts with TF to induce the expression of GBM cell proliferation, motility and survival genes, and participates in the translation of tumor mRNA.
FIGURE 10
FIGURE 10
JAK/STAT signaling pathway.
FIGURE 11
FIGURE 11
MAPK signaling pathway.
FIGURE 12
FIGURE 12
BBB and signal pathways.
See this image and copyright information in PMC

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References

    1. Aaronson D. S., Horvath C. M. (2002). A road map for those who don’t know JAK-STAT. Science 296 1653–1655. 10.1126/science.1071545 - DOI - PubMed
    1. Achanta P., Sedora Roman N. I., Quiñones-Hinojosa A. (2010). Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anti-cancer Agents Med. Chem. 10 121–130. 10.2174/187152010790909290 - DOI - PMC - PubMed
    1. Álvarez-Garcia V., Tawil Y., Wise H. M., Leslie N. R. (2019). Mechanisms of PTEN loss in cancer: it’s all about diversity. Sem. Cancer Biol. 59 66–79. 10.1016/j.semcancer.2019.02.001 - DOI - PubMed
    1. Amin A. G., Jeong S. W., Gillick J. L., Sursal T., Murali R., Gandhi C. D., et al. (2021). Targeting the mTOR pathway using novel ATP-competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma. Int. J. Oncol. 59:83. 10.3892/ijo.2021.5263 - DOI - PMC - PubMed
    1. An B., Ma Y., Xu Y., Liu X., Zhang X., Zhang J., et al. (2020). Crocin regulates the proliferation and migration of neural stem cells after cerebral ischemia by activating the Notch1 pathway. Folia Neuropathol. 58 201–212. 10.5114/fn.2020.100063 - DOI - PubMed