Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 22:13:939433.
doi: 10.3389/fimmu.2022.939433. eCollection 2022.

Knowledge Mapping of Exosomes in Autoimmune Diseases: A Bibliometric Analysis (2002-2021)

Fengping Wu  1 , Jinfang Gao  2 , Jie Kang  3 , Xuexue Wang  3 , Qing Niu  1 , Jiaxi Liu  3 , Liyun Zhang  2
Affiliations

Knowledge Mapping of Exosomes in Autoimmune Diseases: A Bibliometric Analysis (2002-2021)

Fengping Wu et al. Front Immunol. .

Abstract

Background: Autoimmune diseases (AIDs) are a class of chronic disabling diseases characterized by inflammation and damage to muscles, joints, bones, and internal organs. Recent studies have shown that much progress has been made in the research of exosomes in AIDs. However, there is no bibliometric analysis in this research field. This study aims to provide a comprehensive overview of the knowledge structure and research hotspots of exosomes in AIDs through bibliometrics.

Method: Publications related to exosomes in AIDs from 2002 to 2021 were searched on the web of science core collection (WoSCC) database. VOSviewers, CiteSpace and R package "bibliometrix" were used to conduct this bibliometric analysis.

Results: 312 articles from 48 countries led by China and the United States were included. The number of publications related to exosomes in AIDs is increasing year by year. Central South University, Sun Yat Sen University, Tianjin Medical University and University of Pennsylvania are the main research institutions. Frontiers in immunology is the most popular journal in this field, and Journal of Immunology is the most co-cited journal. These publications come from 473 authors among which Ilias Alevizos, Qianjin Lu, Wei Wei, Jim Xiang and Ming Zhao had published the most papers and Clotilde Théry was co-cited most often. Studying the mechanism of endogenous exosomes in the occurrence and development of AIDs and the therapeutic strategy of exogenous exosomes in AIDs are the main topics in this research field. "Mesenchymal stem cells", "microRNA", "biomarkers", "immunomodulation", and "therapy" are the primary keywords of emerging research hotspots.

Conclusion: This is the first bibliometric study that comprehensively summarizes the research trends and developments of exosomes in AIDs. This information identifies recent research frontiers and hot directions, which will provide a reference for scholars studying exosomes.

Keywords: CiteSpace; VOSviewers; autoimmune diseases; bibliometrics; exosomes.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Publications screening flowchart.
Figure 2
Figure 2
Annual output of research of exosomes in AIDs.
Figure 3
Figure 3
The geographical distribution (A) and visualization of countries (B) on research of exosomes in AIDs.
Figure 4
Figure 4
The visualization of institutions on research of exosomes in AIDs.
Figure 5
Figure 5
The visualization of journals (A) and co-cited journals (B) on research of exosomes in AIDs.
Figure 6
Figure 6
The dual-map overlay of journals on research of exosomes in AIDs.
Figure 7
Figure 7
The visualization of authors (A) and co-cited Authors (B) on research of exosomes in AIDs.
Figure 8
Figure 8
The visualization of co-cited references on research of exosomes in AIDs.
Figure 9
Figure 9
Top 13 references with strong citation bursts. A red bar indicates high citations in that year.
Figure 10
Figure 10
Keyword cluster analysis (A) and trend topic analysis (B).
Figure 11
Figure 11
Immunomodulation and tissue repair effects of MSC-Exos in AIDs. MSC-Exos can differentiate immune cells in the direction of suppressing inflammation, reduce the secretion of inflammatory cytokines, and repair damaged tissue cells in the body, such as FLS and β cells. miRNAs are the most studied substances on the mechanisms associated with MSC-Exos in the treatment of AIDs. Tr1, T regulatory type 1 cells; Th 17, T helper 17 effector cells; miR, microRNA; IDO, indoleamine 2,3-dioxygenase; MIC-1, macrophage inhibitory cytokine 1; Gal, galectin-1; HSP70, heat shock protein 70.
See this image and copyright information in PMC

References

    1. Cooper GS, Bynum ML, Somers EC. Recent Insights in the Epidemiology of Autoimmune Diseases: Improved Prevalence Estimates and Understanding of Clustering of Diseases. J Autoimmun (2009) 33(3-4):197–207. doi: 10.1016/j.jaut.2009.09.008 - DOI - PMC - PubMed
    1. Smolen JS, Aletaha D, McInnes IB. Rheumatoid Arthritis. Lancet (2016) 388(10055):2023–38. doi: 10.1016/S0140-6736(16)30173-8 - DOI - PubMed
    1. Cosenza S, Toupet K, Maumus M, Toupet K, Maumus M, Luz-Crawford P, Blanc-Brude O, Jorgensen C, et al. . Mesenchymal Stem Cells-Derived Exosomes are More Immunosuppressive Than Microparticles in Inflammatory Arthritis. Theranostics (2018) 8(5):1399–410. doi: 10.7150/thno.21072 - DOI - PMC - PubMed
    1. Liu H, Li R, Liu T, Yang L, Yin G, Xie Q. Immunomodulatory Effects of Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis. Front Immunol (2020) 11:1912. doi: 10.3389/fimmu.2020.01912 - DOI - PMC - PubMed
    1. Ghafouri-Fard S, Niazi V, Hussen BM, Omrani MD, Taheri M, Basiri A. The Emerging Role of Exosomes in the Treatment of Human Disorders With a Special Focus on Mesenchymal Stem Cells-Derived Exosomes. Front In Cell And Dev Biol (2021) 9. doi: 10.3389/fcell.2021.653296 - DOI - PMC - PubMed

Publication types