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Meta-Analysis
. 2022 Jul 22:13:891822.
doi: 10.3389/fimmu.2022.891822. eCollection 2022.

Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial

Liuting Zeng  1 , Tiejun Yang  2 , Kailin Yang  3 , Ganpeng Yu  2 , Jun Li  2 , Wang Xiang  4 , Hua Chen  1
Affiliations
Meta-Analysis

Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial

Liuting Zeng et al. Front Immunol. .

Abstract

Background: Modern pharmacological research found that the chemical components of Curcuma longa L. are mainly curcumin and turmeric volatile oil. Several recent randomized controlled trials (RCT) have shown that curcumin improves symptoms and inflammation in patients with arthritis.

Methods: Pubmed, Cochran Library, CNKI, and other databases were searched to collect the randomized controlled trials (RCTs). Then, the risk of bias of RCTs were assessed and data of RCTs were extracted. Finally, RevMan 5.3 was utilized for meta-analysis.

Results: Twenty-nine (29) RCTs involving 2396 participants and 5 types of arthritis were included. The arthritis included Ankylosing Spondylitis (AS), Rheumatoid Arthritis (RA), Osteoarthritis (OA), Juvenile idiopathic arthritis (JIA) and gout/hyperuricemia. Curcumin and Curcuma longa Extract were administered in doses ranging from 120 mg to 1500 mg for a duration of 4-36 weeks. In general, Curcumin and Curcuma longa Extract showed safety in all studies and improved the severity of inflammation and pain levels in these arthritis patients. However, more RCTs are needed in the future to elucidate the effect of Curcumin and Curcuma longa Extract supplementation in patients with arthritis, including RA, OA, AS and JIA.

Conclusion: Curcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, due to the low quality and small quantity of RCTs, the conclusions need to be interpreted carefully.

Keywords: Curcuma longa extract; ankylosing spondylitis; curcumin; juvenile idiopathic arthritis; meta-analysis; osteoarthritis; rheumatoid arthritis; systematic review.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of clinical trials.
Figure 2
Figure 2
Risk of bias [(A) graph; (B) summary].
Figure 3
Figure 3
The results of DAS28.
Figure 4
Figure 4
(A) Tender joint count; (B) Swollen joint count.
Figure 5
Figure 5
The results of ESR (A), CRP (B) and RF (C).
Figure 6
Figure 6
Adverse events.
Figure 7
Figure 7
The results of VAS.
Figure 8
Figure 8
WOMAC-pain.
Figure 9
Figure 9
WOMAC-physical function.
Figure 10
Figure 10
WOMAC -stiffness.
Figure 11
Figure 11
The results of ESR (A) and CRP (B).
Figure 12
Figure 12
The results of MDA.
Figure 13
Figure 13
Adverse events.
Figure 14
Figure 14
The mechanism of Curcumin and Curcuma longa Extract in the treatment of arthritis.
See this image and copyright information in PMC

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