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Editorial
. 2022 Jul 22:13:983310.
doi: 10.3389/fimmu.2022.983310. eCollection 2022.

Editorial: Understanding the concept of pre-clinical autoimmunity

Nancy J Olsen  1 , Darin T Okuda  2 , V Michael Holers  3 , David R Karp  4
Affiliations
Editorial

Editorial: Understanding the concept of pre-clinical autoimmunity

Nancy J Olsen et al. Front Immunol. .
No abstract available

Keywords: autoantibodies; autoimme diseases; multiple sclerois; rheumatod arthritis; systemic lupus - erythematosus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Phases of Autoimmunity. The majority of the healthy population has no evidence of cellular or humoral autoimmunity. However, a substantial fraction develops autoantibodies or self-reactive T cells while remaining asymptomatic (1). These individuals typically do not seek medical care unless it is to explain serological findings. After a period of years, characterized by expanding serological autoimmunity and up-regulation of inflammatory cytokines and chemokines, early symptoms develop in a sub-set of people with asymptomatic autoimmunity (2). With the accumulation of sufficient clinical signs and symptoms, patients are classified with definite autoimmune conditions (3). If possible, the prevention of autoimmunity will take place in the earliest phases before there are significant health concerns present. Later clinical treatments will address organ damage and dysfunction but are less likely to halt disease progression over time.
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  • Editorial on the Research Topic Understanding the concept of pre-clinical autoimmunity

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