Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 22:13:724139.
doi: 10.3389/fimmu.2022.724139. eCollection 2022.

Chemokines in progression, chemoresistance, diagnosis, and prognosis of colorectal cancer

Qian Zou  1 , Xue Lei  1 , Aijing Xu  2 , Ziqi Li  1 , Qinglian He  1 , Xiujuan Huang  1   3 , Guangxian Xu  4 , Faqing Tian  1   2 , Yuanlin Ding  5 , Wei Zhu  1
Affiliations
Review

Chemokines in progression, chemoresistance, diagnosis, and prognosis of colorectal cancer

Qian Zou et al. Front Immunol. .

Abstract

Plenty of factors affect the oncogenesis and progression of colorectal cancer in the tumor microenvironment, including various immune cells, stromal cells, cytokines, and other factors. Chemokine is a member of the cytokine superfamily. It is an indispensable component in the tumor microenvironment. Chemokines play an antitumor or pro-tumor role by recruitment or polarization of recruiting immune cells. Meanwhile, chemokines, as signal molecules, participate in the formation of a cross talk among signaling pathways and non-coding RNAs, which may be involved in promoting tumor progression. In addition, they also function in immune escape. Chemokines are related to drug resistance of tumor cells and may even provide reference for the diagnosis, therapy, and prognosis of patients with colorectal cancer.

Keywords: chemokines; colorectal cancer; immune escape; ncRNAs; signal molecules.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The relation between loss of Mothers Against Decapentaplegic Homolog 4 (SMAD4) in human colorectal cancer cells and tumor-infiltrating immune cells and its chemokines and receptors.
Figure 2
Figure 2
Chemokines are involved in the immune evasion.
Figure 3
Figure 3
Chemokines and signaling pathways within cells directly affect each other’s states and the angiogenesis or proliferation and invasion of colorectal cancer.
Figure 4
Figure 4
Excessive alcohol consumption and obesity have an effect on tumorigenesis and development.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wild C, Weiderpass E, Stewart B. World cancer resport: Cancer research for cancer prevention. Lyon: International Agency for Research on Cancer; (2020).
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin (2018) 68(6):394–424. doi: 10.3322/caac.21492 - DOI - PubMed
    1. Wu T, Dai Y. Tumor microenvironment and therapeutic response. Cancer Lett (2017) 387:61–8. doi: 10.1016/j.canlet.2016.01.043 - DOI - PubMed
    1. Meurette O, Mehlen P. Notch signaling in the tumor microenvironment. Cancer Cell (2018) 34(4):536–48. doi: 10.1016/j.ccell.2018.07.009 - DOI - PubMed
    1. Vitale I, Manic G, Coussens LM, Kroemer G, Galluzzi L. Macrophages and metabolism in the tumor microenvironment. Cell Metab (2019) 30(1):36–50. doi: 10.1016/j.cmet.2019.06.001 - DOI - PubMed

Publication types