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Review
. 2022 Jul 27:2022:7360975.
doi: 10.1155/2022/7360975. eCollection 2022.

A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris

Aiai Geng  1   2 , Tianli Pei  1 , Xueyi Zhao  2 , Bo Jia  1
Affiliations
Review

A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris

Aiai Geng et al. Comput Math Methods Med. .

Retraction in

Abstract

Background: Psoriasis is a chronic noncommunicable dermatological condition, and psoriasis vulgaris is the most common phenotype. Acitretin is the most widely used systemic retinoid in the treatment of psoriasis. This review evaluates the clinical therapeutic effects of Xiaoyin granule, a Chinese herbal medicine, combined with acitretin capsule in the treatment of psoriasis vulgaris.

Methods: Six databases including PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Wan Fang, and China Biology Medicine disc (CBM) were searched for published studies on Xiaoyin granule and/or acitretin capsule in psoriasis vulgaris. The Cochrane Collaboration risk-of-bias instrument was used to assess the quality of the included RCTs. STATA 14.0 was used to conduct the statistical analysis.

Results: Twenty-eight trials with 3281 patients were included in this meta-analysis. The results of this study show that the combined treatment of Xiaoyin granule and acitretin capsule could improve the total effective rate (TER) and cure rate (CR) when compared with acitretin capsule (TER: RR = 1.15, 95% CI (1.10, 1.21); CR: RR = 1.8, 95% CI (1.62, 2.00)) or Xiaoyin granule (TER: RR = 1.24, 95% CI (1.11, 1.39); CR: RR = 1.75, 95% CI (1.54, 1.98)) alone. The combined therapy could decrease the PASI score (mean difference = -1.45, 95% CI (-2.09, -0.80)) and inhibit inflammation (IL-10: mean difference = 1.16, 95% CI (0.94, 1.38); IL-17: mean difference = -2.06, 95% CI (-2.60, -1.51)) in psoriasis vulgaris patients.

Conclusions: The combination of Xiaoyin granule and acitretin capsules could be a novel therapeutic strategy in the treatment of psoriasis vulgaris. However, the quality of trials in this study limited the conclusion, and more high-quality RCTs are needed for further evaluation.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of study selection.
Figure 2
Figure 2
Quality and bias assessment: (a) risk of bias for each RCT; (b) risk of bias summary.
Figure 3
Figure 3
Therapeutic effects of acitretin combined with Xiaoyin versus acitretin alone: (a) total effective rate; (b) cure rate.
Figure 4
Figure 4
Therapeutic effects of acitretin combined with Xiaoyin versus Xiaoyin alone: (a) total effective rate; (b) cure rate.
Figure 5
Figure 5
Subgroup analyses of total effective rate on sample size: (a) acitretin+Xiaoyin versus acitretin; (b) acitretin+Xiaoyin versus Xiaoyin.
Figure 6
Figure 6
Meta-analysis of PASI score. Acitretin+Xiaoyin versus acitretin.
Figure 7
Figure 7
Meta-analyses of IL-10 and IL-17 expression. Acitretin+Xiaoyin versus acitretin: (a) IL-10; (b) IL-17.
Figure 8
Figure 8
Funnel plots of publication bias: (a, b) total effective rate and cure rate of acitretin+Xiaoyin versus acitretin; (c, d) total effective rate and cure rate of acitretin+Xiaoyin versus Xiaoyin; (e) PASI score; (f) IL-10 expression; (g) IL-17 expression.
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