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. 2022 May-Jun;25(3):401-406.
doi: 10.4103/aian.aian_121_22. Epub 2022 Jun 14.

Impact of Antecedent Infections on the Antibodies against Gangliosides and Ganglioside Complexes in Guillain-Barré Syndrome: A Correlative Study

Debprasad Dutta  1 , Monojit Debnath  1 , Doniparthi V Seshagiri  2 , Binu V Sreekumaran Nair  3 , Sumit K Das  3 , Rahul Wahatule  2 , Sanjib Sinha  2 , Vasanthapuram Ravi  4 , Arun B Taly  2 , Madhu Nagappa  2
Affiliations

Impact of Antecedent Infections on the Antibodies against Gangliosides and Ganglioside Complexes in Guillain-Barré Syndrome: A Correlative Study

Debprasad Dutta et al. Ann Indian Acad Neurol. 2022 May-Jun.

Abstract

Background and aims: Guillain-Barré Syndrome (GBS), an immune-mediated neuropathy, is characterized by antibodies against gangliosides/ganglioside complexes (GSCs) of peripheral nerves. Antecedent infections have been reported to induce antibodies that cross-react with the host gangliosides and thereby have a pivotal role in conferring an increased risk for developing GBS. Data pertaining to the impact of various antecedent infections, particularly those prevalent in tropical countries like India on the ganglioside/GSC antibodies is sparse. We aimed at exploring the association between six antecedent infections and the profile of ganglioside/GSC antibodies in GBS.

Methods: Patients with GBS (n = 150) and healthy controls (n = 50) were examined for the serum profile of antibodies against GM1, GM2, GD1a, GD1b, GT1b, and GQ1b and their GSCs by ELISA. These antibodies were correlated with immunoreactivities against Campylobacter jejuni, Japanese encephalitis (JE), dengue, influenza, zika, and chikungunya infections.

Results: The frequencies of antibodies against six single gangliosides (P < 0.001) and their GSCs (P = 0.039) were significantly higher in patients as compared to controls. Except for GT1b-antibody which was more frequent in axonal GBS, none of the other ganglioside/GSC antibodies correlated with the electrophysiological subtypes of GBS. Antecedent JE infection was significantly associated with increased frequency of antibodies against GD1a, GD1b, GT1b, and GQ1b. Antibodies against GSCs were not influenced by the antecedent infections.

Interpretation: This study for the first time shows an association between antecedent JE infection and ganglioside antibodies in GBS. This finding reinforces the determining role of antecedent infections on ganglioside antibody responses and the subsequent immunological processes in GBS.

Keywords: Antecedent infections; Guillain-Barré syndrome; Japanese encephalitis virus; autoantibodies; ganglioside complex; gangliosides.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Autoantibodies against various ganglioside complexes (GSCs) in patients with Guillain-Barré syndrome
See this image and copyright information in PMC

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