Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 22:12:956926.
doi: 10.3389/fonc.2022.956926. eCollection 2022.

New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance

Audrey Sirvent  1 , Kevin Espie  1 , Evangelia Papadopoulou  1 , Dana Naim  1 , Serge Roche  1
Affiliations
Review

New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance

Audrey Sirvent et al. Front Oncol. .

Abstract

The tumor microenvironment facilitates cancer progression and therapeutic resistance. Tumor collagens and their architecture play an essential role in this process. However, little is known about the mechanisms by which tumor cells sense and respond to this extracellular matrix environment. Recently, the Discoidin Domain Receptor 1 (DDR1), a collagen receptor and tyrosine kinase has emerged as an important player in this malignant process, although the underlying signaling mechanisms remain unclear. Here, we review new DDR1 functions in tumor dormancy following dissemination, immune exclusion and therapeutic resistance induced by stromal collagens deposition. We also discuss the signaling mechanisms behind these tumor activities and the therapeutic strategies aiming at targeting these collagens-dependent tumor responses.

Keywords: Keywords: collagen; immune evasion; metastasis; receptor; therapeutic resistance; tumor dormancy; tumor microenvironment; tyrosine kinase.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance. (A) A model on DDR1 signaling during DTC dormancy and metastatic reactivation induced by TME collagens. (B) A model on DDR1 signaling during therapeutic resistance and immune exclusion induced TME collagens.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell (2011) 144:646–74. doi: 10.1016/j.cell.2011.02.013 - DOI - PubMed
    1. Hanahan D. Hallmarks of cancer: New dimensions. Cancer Discov (2022) 12:31–46. doi: 10.1158/2159-8290.CD-21-1059 - DOI - PubMed
    1. Pickup MW, Mouw JK, Weaver VM. The extracellular matrix modulates the hallmarks of cancer. EMBO Rep (2014) 15:1243–53. doi: 10.15252/embr.201439246 - DOI - PMC - PubMed
    1. Xu S, Xu H, Wang W, Li S, Li H, Li T, et al. . The role of collagen in cancer: From bench to bedside. J Transl Med (2019) 17:309. doi: 10.1186/s12967-019-2058-1 - DOI - PMC - PubMed
    1. Cox TR. The matrix in cancer. Nat Rev Cancer (2021) 21:217–38. doi: 10.1038/s41568-020-00329-7 - DOI - PubMed

LinkOut - more resources